Hs05425824_cn

• Gene Symbol: E2F4
• Assay Reference Genome Location: Chr.16:67197141 on build GRCh38
• Cytoband: 16q22.1

Target Gene Details

• Entrez Gene ID: 1874
• Gene Name: E2F transcription factor 4
• Gene Aliases: E2F-4
• Location: Chr.16:67192165-67198918 on Build GRCh38
• Assay Gene Location: Within Intron 7

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
E2F4	NM_001950.3			NP_001941.2
	AB451292.1
	AB451425.1
	BC033180.1			AAH33180.1
	S75174.1			AAB32597.1
	U15641.1			AAC50119.1
	X86096.1			CAA60050.2

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv522852	Chr.16:67153308 - 68071571 on Build GRCh38	Gain	RANBP10 ACD PSKH1 C16orf86 NUTF2 FBXL8 LOC105369155 CTCF HSD11B2 CENPT ATP6V0D1 TMEM208 LRRC36 EDC4 ELMO3 LOC100131303 ENKD1 CARMIL2 DDX28 KIAA0895L PARD6A DPEP3 EXOC3L1 KCTD19 DPEP2 E2F4 FHOD1 AGRP CTRL MIR328 SLC9A5 NRN1L LRRC29 LCAT NOL3 TPPP3 TRADD HSF4 TSNAXIP1 ZDHHC1 LOC100505942 PLEKHG4 DUS2 LOC107984813 SLC12A4 THAP11 PSMB10 FAM65A GFOD2
nsv827707	Chr.16:67148355 - 67289296 on Build GRCh38	Loss	E2F4 TMEM208 FHOD1 ELMO3 FBXL8 LOC105369155 MIR328 SLC9A5 PLEKHG4 LRRC29 NOL3 B3GNT9 C16orf70 KIAA0895L TRADD EXOC3L1 HSF4
nsv952044	Chr.16:67141198 - 67244397 on Build GRCh38	Deletion	E2F4 TMEM208 FHOD1 ELMO3 FBXL8 LOC105369155 MIR328 LRRC29 NOL3 B3GNT9 C16orf70 KIAA0895L TRADD EXOC3L1 HSF4
nsv1160429	Chr.16:67161549 - 67220197 on Build GRCh38	Deletion	LRRC29 E2F4 NOL3 KIAA0895L ELMO3 FBXL8 LOC105369155 EXOC3L1 MIR328 HSF4
nsv457513	Chr.16:67181417 - 67282697 on Build GRCh38	Loss	LRRC29 E2F4 TMEM208 FHOD1 KIAA0895L ELMO3 LOC105369155 EXOC3L1 MIR328 SLC9A5 PLEKHG4
nsv524492	Chr.16:67174030 - 67294550 on Build GRCh38	Loss	E2F4 TMEM208 FHOD1 ELMO3 LOC105369155 MIR328 SLC9A5 PLEKHG4 LRRC29 NOL3 KIAA0895L EXOC3L1 KCTD19
nsv524363	Chr.16:67136529 - 68071571 on Build GRCh38	Loss	RANBP10 ACD PSKH1 C16orf86 NUTF2 FBXL8 LOC105369155 CTCF HSD11B2 CENPT ATP6V0D1 TMEM208 LRRC36 EDC4 ELMO3 LOC100131303 ENKD1 CARMIL2 C16orf70 DDX28 KIAA0895L PARD6A DPEP3 EXOC3L1 KCTD19 DPEP2 E2F4 FHOD1 AGRP CTRL MIR328 SLC9A5 NRN1L LRRC29 LCAT NOL3 B3GNT9 TPPP3 TRADD HSF4 TSNAXIP1 ZDHHC1 LOC100505942 PLEKHG4 DUS2 LOC107984813 SLC12A4 THAP11 PSMB10 FAM65A GFOD2

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

RNA metabolism protein, nucleic acid metabolism protein, general transcription factor

Gene Ontology Categories:

Process(es)

regulation of transcription involved in G1/S transition of mitotic cell cycle
epithelial cell development
transcription from RNA polymerase II promoter
cell volume homeostasis
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
blood circulation
organ morphogenesis
regulation of cell proliferation
motile cilium assembly
positive regulation of transcription from RNA polymerase II promoter
centriole assembly
multi-ciliated epithelial cell differentiation

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
transcription factor binding
protein domain specific binding
promoter-specific chromatin binding