Hs05460399_cn

• Gene Symbol: E2F4
• Assay Reference Genome Location: Chr.16:67196402 on build GRCh38
• Cytoband: 16q22.1

Target Gene Details

• Entrez Gene ID: 1874
• Gene Name: E2F transcription factor 4
• Gene Aliases: E2F-4
• Location: Chr.16:67192165-67198918 on Build GRCh38
• Assay Gene Location: Within Intron 7

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
E2F4	NM_001950.3			NP_001941.2
	AB451292.1
	AB451425.1
	BC033180.1			AAH33180.1
	S75174.1			AAB32597.1
	U15641.1			AAC50119.1
	X86096.1			CAA60050.2

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv522852	Chr.16:67153308 - 68071571 on Build GRCh38	Gain	ZDHHC1 CARMIL2 ACD ENKD1 DPEP3 NRN1L NUTF2 HSD11B2 ATP6V0D1 EDC4 GFOD2 KCTD19 LRRC29 SLC12A4 CTRL LRRC36 HSF4 CTCF TMEM208 SLC9A5 LOC100505942 C16orf86 LOC100131303 FBXL8 PSKH1 CENPT LOC107984813 TPPP3 E2F4 MIR328 TSNAXIP1 DDX28 NOL3 RANBP10 PARD6A KIAA0895L EXOC3L1 TRADD PLEKHG4 THAP11 PSMB10 FAM65A LCAT FHOD1 ELMO3 LOC105369155 DUS2 AGRP DPEP2
nsv827707	Chr.16:67148355 - 67289296 on Build GRCh38	Loss	FBXL8 PLEKHG4 HSF4 E2F4 MIR328 FHOD1 TMEM208 SLC9A5 ELMO3 NOL3 LOC105369155 KIAA0895L EXOC3L1 LRRC29 B3GNT9 C16orf70 TRADD
nsv952044	Chr.16:67141198 - 67244397 on Build GRCh38	Deletion	FBXL8 HSF4 E2F4 MIR328 FHOD1 TMEM208 ELMO3 NOL3 LOC105369155 KIAA0895L EXOC3L1 LRRC29 B3GNT9 C16orf70 TRADD
nsv1160429	Chr.16:67161549 - 67220197 on Build GRCh38	Deletion	FBXL8 NOL3 LOC105369155 HSF4 KIAA0895L EXOC3L1 E2F4 MIR328 LRRC29 ELMO3
nsv457513	Chr.16:67181417 - 67282697 on Build GRCh38	Loss	PLEKHG4 LOC105369155 KIAA0895L EXOC3L1 E2F4 MIR328 LRRC29 FHOD1 TMEM208 SLC9A5 ELMO3
nsv524492	Chr.16:67174030 - 67294550 on Build GRCh38	Loss	PLEKHG4 E2F4 MIR328 FHOD1 TMEM208 SLC9A5 ELMO3 NOL3 LOC105369155 KIAA0895L EXOC3L1 KCTD19 LRRC29
nsv524363	Chr.16:67136529 - 68071571 on Build GRCh38	Loss	ZDHHC1 CARMIL2 ACD ENKD1 DPEP3 NRN1L NUTF2 HSD11B2 ATP6V0D1 EDC4 GFOD2 KCTD19 LRRC29 C16orf70 SLC12A4 CTRL LRRC36 HSF4 CTCF TMEM208 SLC9A5 LOC100505942 C16orf86 LOC100131303 FBXL8 PSKH1 CENPT LOC107984813 TPPP3 E2F4 MIR328 TSNAXIP1 DDX28 NOL3 RANBP10 PARD6A KIAA0895L EXOC3L1 TRADD PLEKHG4 THAP11 PSMB10 FAM65A LCAT FHOD1 ELMO3 LOC105369155 DUS2 AGRP B3GNT9 DPEP2

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

RNA metabolism protein, nucleic acid metabolism protein, general transcription factor

Gene Ontology Categories:

Process(es)

regulation of transcription involved in G1/S transition of mitotic cell cycle
epithelial cell development
transcription from RNA polymerase II promoter
cell volume homeostasis
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
blood circulation
organ morphogenesis
regulation of cell proliferation
motile cilium assembly
positive regulation of transcription from RNA polymerase II promoter
centriole assembly
multi-ciliated epithelial cell differentiation

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
transcription factor binding
protein domain specific binding
promoter-specific chromatin binding