Hs05888550_cn

• Gene Symbol: MYLK
• Assay Reference Genome Location: Chr.3:123690813 on build GRCh38
• Cytoband: 3q21.1

Target Gene Details

• Entrez Gene ID: 4638
• Gene Name: myosin light chain kinase
• Gene Aliases: AAT7, KRP, MLCK, MLCK1, MLCK108, MLCK210, MSTP083, MYLK1, smMLCK
• Location: Chr.3:123612296-123884302 on Build GRCh38
• Assay Gene Location: Within Intron 20

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
MYLK	NM_001321309.1			NP_001308238.1
	NM_053025.3			NP_444253.3
	NM_053026.3			NP_444254.3
	NM_053027.3			NP_444255.3
	NM_053028.3			NP_444256.3
	XM_011512860.2			XP_011511162.1
	XM_011512861.2			XP_011511163.1
	XM_017006469.1			XP_016861958.1
	XM_017006470.1			XP_016861959.1
	XM_017006471.1			XP_016861960.1
	AB037663.1			BAB21504.1
	AF069601.2			AAD15921.2
	AF069602.1			AAD15922.1
	AF069603.1			AAD15923.1
	AK300610.1
	AY339601.1			AAQ02673.1
	AY424269.1			AAR29061.1
	AY424270.1			AAR29062.1
	U48959.2			AAC18423.2
	X85337.1			CAA59685.1

Target Gene Details

• Entrez Gene ID: 100873940
• Gene Name: MYLK antisense RNA 2
• Gene Aliases: -
• Location: Chr.3:123689644-123692407 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
MYLK-AS2	NR_046629.1
	AI148949.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv829710	Chr.3:123641413 - 123825722 on Build GRCh38	Gain	MYLK-AS2 MYLK
nsv591428	Chr.3:123608828 - 124139902 on Build GRCh38	Gain	MYLK-AS1 KALRN MYLK-AS2 MIR5002 MYLK ROPN1 CCDC14
nsv829708	Chr.3:123519589 - 123690957 on Build GRCh38	Gain	MYLK-AS1 HACD2 MYLK-AS2 MYLK
nsv829709	Chr.3:123554281 - 123748120 on Build GRCh38	Loss	MYLK-AS1 HACD2 MYLK-AS2 MYLK

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

positive regulation of defense response to virus by host
protein phosphorylation
muscle contraction
smooth muscle contraction
tonic smooth muscle contraction
positive regulation of cell migration
bleb assembly
positive regulation of calcium ion transport
aorta smooth muscle tissue morphogenesis
cellular hypotonic response
positive regulation of wound healing
mitophagy in response to mitochondrial depolarization
xenophagy

Function(s)

actin binding
myosin light chain kinase activity
protein binding
calmodulin binding
ATP binding
metal ion binding