Hs05903545_cn

• Gene Symbol: NCK1
• Assay Reference Genome Location: Chr.3:136917894 on build GRCh38
• Cytoband: 3q22.3

Target Gene Details

• Entrez Gene ID: 4690
• Gene Name: NCK adaptor protein 1
• Gene Aliases: NCK, NCKalpha, nck-1
• Location: Chr.3:136862208-136951610 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
NCK1	NM_001291999.1			NP_001278928.1
	NM_006153.5			NP_006144.1
	AK312692.1
	BC006403.2			AAH06403.1
	DA265476.1
	DA855124.1
	DB117533.1
	X17576.1			CAA35599.1

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, non-DGV Variation

Panther Classification:

Molecular Function -

scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

negative regulation of protein kinase activity
substrate-dependent cell migration, cell extension
actin filament organization
signal complex assembly
vesicle-mediated transport
lamellipodium assembly
positive regulation of actin filament polymerization
negative regulation of peptidyl-serine phosphorylation
positive regulation of translation in response to endoplasmic reticulum stress
Fc-gamma receptor signaling pathway involved in phagocytosis
positive regulation of T cell proliferation
T cell activation
positive regulation of GTPase activity
positive regulation of transcription from RNA polymerase II promoter
vascular endothelial growth factor receptor signaling pathway
T cell receptor signaling pathway
response to other organism
negative regulation of cell death
peptidyl-serine dephosphorylation
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
positive regulation of cap-dependent translational initiation
positive regulation of cap-independent translational initiation
negative regulation of PERK-mediated unfolded protein response
negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

Function(s)

protein kinase inhibitor activity
SH3/SH2 adaptor activity
ARF guanyl-nucleotide exchange factor activity
receptor binding
protein binding
cytoskeletal adaptor activity
protein domain specific binding
receptor signaling complex scaffold activity
protein binding, bridging
receptor tyrosine kinase binding
eukaryotic initiation factor eIF2 binding
cadherin binding involved in cell-cell adhesion