Hs05926321_cn

• Gene Symbol: KLKB1
• Assay Reference Genome Location: Chr.4:186230918 on build GRCh38
• Cytoband: 4q35.2

Target Gene Details

• Entrez Gene ID: 3818
• Gene Name: kallikrein B1
• Gene Aliases: KLK3, PKK, PKKD, PPK
• Location: Chr.4:186215714-186258477 on Build GRCh38
• Assay Gene Location: Within Intron 4

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
KLKB1	NM_000892.4			NP_000883.2
	NM_001318394.1			NP_001305323.1
	NM_001318396.1			NP_001305325.1
	XM_011531930.2			XP_011530232.1
	XM_017008181.1			XP_016863670.1
	XM_017008182.1			XP_016863671.1
	XM_017008183.1			XP_016863672.1
	AK292624.1
	AK297672.1
	AK313378.1
	BC117349.1
	BC117351.1
	CN265612.1
	M13143.2			AAA60153.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1028146	Chr.4:185582745 - 186417181 on Build GRCh38	Gain	FAM149A FLJ38576 CYP4V2 F11-AS1 SORBS2 F11 TLR3 KLKB1
nsv830172	Chr.4:186091611 - 186247270 on Build GRCh38	Loss	FAM149A FLJ38576 CYP4V2 KLKB1
nsv461864	Chr.4:186085652 - 186335850 on Build GRCh38	Gain	FAM149A FLJ38576 CYP4V2 F11-AS1 F11 TLR3 KLKB1
nsv596401	Chr.4:186151229 - 186445495 on Build GRCh38	Loss	FAM149A FLJ38576 CYP4V2 F11-AS1 F11 KLKB1

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

serine protease

Gene Ontology Categories:

Process(es)

Factor XII activation
proteolysis
blood coagulation, intrinsic pathway
extracellular matrix disassembly
zymogen activation
plasminogen activation
fibrinolysis
positive regulation of fibrinolysis
liver regeneration

Function(s)

serine-type endopeptidase activity
protein binding