Hs05977673_cn

• Gene Symbol: CNOT8
• Assay Reference Genome Location: Chr.5:154863702 on build GRCh38
• Cytoband: 5q33.2

Target Gene Details

• Entrez Gene ID: 9337
• Gene Name: CCR4-NOT transcription complex subunit 8
• Gene Aliases: CAF1, CALIF, Caf1b, POP2, hCAF1
• Location: Chr.5:154857952-154876792 on Build GRCh38
• Assay Gene Location: Within Intron 3

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
CNOT8	NM_001301073.1			NP_001288002.1
	NM_001301074.1			NP_001288003.1
	NM_001301075.1			NP_001288004.1
	NM_001301077.1			NP_001288006.1
	NM_001301080.1			NP_001288009.1
	NM_001301082.1			NP_001288011.1
	NM_001301083.1			NP_001288012.1
	NM_001301086.1			NP_001288015.1
	NM_004779.5			NP_004770.4
	XM_005268527.2			XP_005268584.1
	XM_011537706.1			XP_011536008.1
	XM_011537708.2			XP_011536010.1
	XM_017010048.1			XP_016865537.1
	XM_017010049.1			XP_016865538.1
	XM_017010050.1			XP_016865539.1
	XM_017010051.1			XP_016865540.1
	XM_017010052.1			XP_016865541.1
	XM_017010053.1			XP_016865542.1
	XM_017010054.1			XP_016865543.1
	XM_017010055.1			XP_016865544.1
	XM_017010056.1			XP_016865545.1
	XM_017010057.1			XP_016865546.1
	XM_017010058.1			XP_016865547.1
	AF053318.1			AAD02685.1
	AF087844.1			AAP97157.1
	AF180476.1			AAF29830.1
	AK025358.1			BAB15119.1
	AK297381.1
	AK299589.1
	AK303775.1
	AK309359.1
	AK314317.1
	AK315864.1
	AK316055.1
	AK316221.1
	AK316269.1
	AL122045.1			CAB59181.1
	AL520837.3
	BC017366.2			AAH17366.1
	BT006857.1			AAP35503.1
	DC387160.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv830521	Chr.5:154768007 - 154864706 on Build GRCh38	Gain	CNOT8 FAXDC2 LARP1 MIR378H

More Information

Additional Information:

For this assay, SNP(s) [rs73278808] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

mRNA polyadenylation factor

Gene Ontology Categories:

Process(es)

nuclear-transcribed mRNA poly(A) tail shortening
transcription, DNA-templated
regulation of transcription, DNA-templated
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
positive regulation of cell proliferation
negative regulation of cell proliferation
gene silencing by miRNA
exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
positive regulation of mRNA catabolic process
RNA phosphodiester bond hydrolysis, exonucleolytic

Function(s)

3'-5'-exoribonuclease activity
transcription factor activity, sequence-specific DNA binding
RNA binding
poly(A)-specific ribonuclease activity
protein binding
metal ion binding