Hs06272371_cn

• Gene Symbol: RDX
• Assay Reference Genome Location: Chr.11:110181818 on build GRCh38
• Cytoband: 11q22.3

Target Gene Details

• Entrez Gene ID: 5962
• Gene Name: radixin
• Gene Aliases: DFNB24
• Location: Chr.11:110174880-110296712 on Build GRCh38
• Assay Gene Location: Within Intron 16

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
RDX	NM_001260493.1			NP_001247422.1
	DQ916741.1
	DQ916742.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1159937	Chr.11:110169507 - 110182165 on Build GRCh38	Deletion	RDX ZC3H12C
nsv832265	Chr.11:110041489 - 110225405 on Build GRCh38	Gain	RDX ZC3H12C

More Information

Additional Information:

For this assay, SNP(s) [rs117058925] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

actin or actin-binding cytoskeletal protein

Gene Ontology Categories:

Process(es)

regulation of cell shape
regulation of cell size
positive regulation of gene expression
protein kinase A signaling
microvillus assembly
positive regulation of cell migration
regulation of actin filament bundle assembly
regulation of Rap protein signal transduction
negative regulation of homotypic cell-cell adhesion
negative regulation of GTPase activity
regulation of GTPase activity
apical protein localization
establishment of protein localization
negative regulation of cell size
actin filament capping
establishment of endothelial barrier
establishment of protein localization to plasma membrane
cellular response to thyroid hormone stimulus
cell-cell adhesion
regulation of ruffle assembly
positive regulation of G1/S transition of mitotic cell cycle
regulation of organelle assembly
positive regulation of protein localization to early endosome
positive regulation of cellular protein catabolic process
negative regulation of adherens junction organization
positive regulation of early endosome to late endosome transport

Function(s)

actin binding
protein binding
protein domain specific binding
protein homodimerization activity
poly(A) RNA binding
protein kinase A binding
ATPase binding
cadherin binding involved in cell-cell adhesion