Hs06313652_cn

• Gene Symbol: GRK2
• Assay Reference Genome Location: Chr.11:67268026 on build GRCh38
• Cytoband: 11q13.2

Target Gene Details

• Entrez Gene ID: 156
• Gene Name: G protein-coupled receptor kinase 2
• Gene Aliases: ADRBK1, BARK1, BETA-ARK1
• Location: Chr.11:67266420-67286558 on Build GRCh38
• Assay Gene Location: Within Intron 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
GRK2	NM_001619.3			NP_001610.2
	XM_011544773.1			XP_011543075.1
	BC037963.1			AAH37963.1
	BC090863.1			AAH90863.1
	DN989901.1
	KU177896.1
	KU177897.1
	M80776.1			AAA58391.1
	X61157.1			CAA43470.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv555253	Chr.11:67265605 - 67397024 on Build GRCh38	Loss	SSH3 RAD9A POLD4 LOC100130987 ANKRD13D CLCF1 GRK2

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

non-receptor serine/threonine protein kinase

Gene Ontology Categories:

Process(es)

desensitization of G-protein coupled receptor protein signaling pathway
negative regulation of the force of heart contraction by chemical signal
G-protein coupled acetylcholine receptor signaling pathway
tachykinin receptor signaling pathway
heart development
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
viral genome replication
receptor internalization
positive regulation of catecholamine secretion
negative regulation of striated muscle contraction
viral entry into host cell
cardiac muscle contraction

Function(s)

protein kinase activity
G-protein coupled receptor kinase activity
protein binding
ATP binding
alpha-2A adrenergic receptor binding
Edg-2 lysophosphatidic acid receptor binding
beta-adrenergic receptor kinase activity