Hs06446814_cn

• Gene Symbol: PTPN2
• Assay Reference Genome Location: Chr.18:12824749 on build GRCh38
• Cytoband: 18p11.21

Target Gene Details

• Entrez Gene ID: 5771
• Gene Name: protein tyrosine phosphatase, non-receptor type 2
• Gene Aliases: PTN2, PTPT, TC-PTP, TCELLPTP, TCPTP
• Location: Chr.18:12785478-12884351 on Build GRCh38
• Assay Gene Location: Within Intron 7

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PTPN2	NM_001207013.1			NP_001193942.1
	NM_001308287.1			NP_001295216.1
	NM_002828.3			NP_002819.2
	NM_080422.2			NP_536347.1
	NM_080423.2			NP_536348.1
	XM_005258124.3			XP_005258181.1
	XM_005258125.3			XP_005258182.1
	XM_011525705.2			XP_011524007.1
	XM_011525706.2			XP_011524008.1
	XM_017025884.1			XP_016881373.1
	XM_017025885.1			XP_016881374.1
	XM_017025886.1			XP_016881375.1
	XM_017025887.1			XP_016881376.1
	XM_017025888.1			XP_016881377.1
	AB209569.1			BAD92806.1
	AK225706.1
	AK290649.1
	AK292570.1
	BC008244.1			AAH08244.1
	BC016727.1			AAH16727.1
	M25393.1			AAA65997.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1064273	Chr.18:12697602 - 12828252 on Build GRCh38	Gain	PSMG2 CEP76 PTPN2 LOC100996324
nsv1063125	Chr.18:12046893 - 12918252 on Build GRCh38	Loss	PRELID3A SPIRE1 CIDEA ANKRD62 TUBB6 PTPN2 C18orf61 AFG3L2 PSMG2 CEP76 LOC100996333 LOC105371998 LOC100996324

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

protein phosphatase

Gene Ontology Categories:

Process(es)

negative regulation of cell proliferation
insulin receptor signaling pathway
negative regulation of tumor necrosis factor-mediated signaling pathway
negative regulation of lipid storage
B cell differentiation
T cell differentiation
erythrocyte differentiation
peptidyl-tyrosine dephosphorylation
negative regulation of epidermal growth factor receptor signaling pathway
negative regulation of tyrosine phosphorylation of Stat1 protein
negative regulation of tyrosine phosphorylation of Stat5 protein
negative regulation of tyrosine phosphorylation of Stat6 protein
glucose homeostasis
negative regulation of macrophage differentiation
positive regulation of gluconeogenesis
negative regulation of insulin receptor signaling pathway
negative regulation of inflammatory response
negative regulation of T cell receptor signaling pathway
negative regulation of chemotaxis
regulation of interferon-gamma-mediated signaling pathway
negative regulation of interferon-gamma-mediated signaling pathway
negative regulation of type I interferon-mediated signaling pathway
negative regulation of protein tyrosine kinase activity
negative regulation of interleukin-6-mediated signaling pathway
negative regulation of ERK1 and ERK2 cascade
regulation of hepatocyte growth factor receptor signaling pathway
negative regulation of interleukin-2-mediated signaling pathway
negative regulation of prolactin signaling pathway
negative regulation of interleukin-4-mediated signaling pathway
negative regulation of macrophage colony-stimulating factor signaling pathway
negative regulation of positive thymic T cell selection
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
positive regulation of PERK-mediated unfolded protein response
negative regulation of platelet-derived growth factor receptor-beta signaling pathway

Function(s)

protein tyrosine phosphatase activity
non-membrane spanning protein tyrosine phosphatase activity
integrin binding
protein binding
protein kinase binding
syntaxin binding
receptor tyrosine kinase binding