Hs06822207_cn

• Gene Symbol: FOXO3
• Assay Reference Genome Location: Chr.6:108586126 on build GRCh38
• Cytoband: 6q21

Target Gene Details

• Entrez Gene ID: 2309
• Gene Name: forkhead box O3
• Gene Aliases: AF6q21, FKHRL1, FKHRL1P2, FOXO2, FOXO3A
• Location: Chr.6:108559823-108684769 on Build GRCh38
• Assay Gene Location: Within Exon 5

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
FOXO3	NM_001455.3			NP_001446.1
	NM_201559.2			NP_963853.1
	XM_005266867.4			XP_005266924.1
	XM_011535626.1			XP_011533928.1
	XM_011535628.2	1	804	XP_011533930.1
	XM_017010585.1			XP_016866074.1
	XM_017010586.1			XP_016866075.1
	AF032886.1			AAC39592.1
	AJ001589.1			CAA04860.1
	AK092357.1
	AK122861.1
	BC020227.1			AAH20227.1
	BC021224.2			AAH21224.1
	BC068552.1			AAH68552.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv950491	Chr.6:108574598 - 108653697 on Build GRCh38	Duplication	FOXO3
nsv830767	Chr.6:108476568 - 108667716 on Build GRCh38	Gain	LACE1 FOXO3

More Information

Additional Information:

For this assay, SNP(s) [rs114540116] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Exonic, DGV Variation

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
ovulation from ovarian follicle
initiation of primordial ovarian follicle growth
antral ovarian follicle growth
oocyte maturation
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
regulation of translation
DNA damage response, signal transduction by p53 class mediator
tumor necrosis factor-mediated signaling pathway
cellular response to oxidative stress
glucose homeostasis
positive regulation of apoptotic process
positive regulation of neuron apoptotic process
positive regulation of erythrocyte differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of canonical Wnt signaling pathway
neuronal stem cell population maintenance
extrinsic apoptotic signaling pathway in absence of ligand
regulation of neural precursor cell proliferation
regulation of reactive oxygen species metabolic process

Function(s)

core promoter binding
transcription cofactor binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
beta-catenin binding
protein kinase binding
chromatin DNA binding
sequence-specific DNA binding