Hs07016884_cn

• Gene Symbol: KRAS
• Assay Reference Genome Location: Chr.12:25211777 on build GRCh38
• Cytoband: 12p12.1

Target Gene Details

• Entrez Gene ID: 3845
• Gene Name: KRAS proto-oncogene, GTPase
• Gene Aliases: C-K-RAS, CFC2, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, KI-RAS, KRAS1, KRAS2, NS, NS3, RALD, RASK2
• Location: Chr.12:25204789-25252093 on Build GRCh38
• Assay Gene Location: Within Intron 6

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
KRAS	NM_004985.4			NP_004976.2
	NM_033360.3			NP_203524.1
	XM_006719069.3			XP_006719132.1
	XM_011520653.2			XP_011518955.1
	XM_017019293.1			XP_016874782.1
	AF493917.1			AAM12631.1
	AI539465.1
	AK292510.1
	BC013572.2			AAH13572.1
	BT007153.1			AAP35817.1
	M54968.1			AAB41942.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv557798	Chr.12:25206907 - 25244348 on Build GRCh38	Loss	KRAS
nsv1048631	Chr.12:25200583 - 25225727 on Build GRCh38	Loss	LYRM5 KRAS

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

small GTPase

Gene Ontology Categories:

Process(es)

MAPK cascade
positive regulation of protein phosphorylation
stimulatory C-type lectin receptor signaling pathway
epidermal growth factor receptor signaling pathway
Ras protein signal transduction
axon guidance
positive regulation of cell proliferation
visual learning
positive regulation of gene expression
cytokine-mediated signaling pathway
forebrain astrocyte development
actin cytoskeleton organization
regulation of protein stability
regulation of synaptic transmission, GABAergic
positive regulation of Rac protein signal transduction
social behavior
endocrine signaling
Fc-epsilon receptor signaling pathway
ERBB2 signaling pathway
positive regulation of MAP kinase activity
negative regulation of neuron apoptotic process
negative regulation of cell differentiation
regulation of long-term neuronal synaptic plasticity
homeostasis of number of cells within a tissue
leukocyte migration
positive regulation of nitric-oxide synthase activity
positive regulation of NF-kappaB transcription factor activity
striated muscle cell differentiation
response to glucocorticoid
response to mineralocorticoid
epithelial tube branching involved in lung morphogenesis

Function(s)

GTPase activity
protein binding
GTP binding
GMP binding
GDP binding
LRR domain binding
protein complex binding