Hs07017182_cn

• Gene Symbol: SIRT4
• Assay Reference Genome Location: Chr.12:120297726 on build GRCh38
• Cytoband: 12q24.23

Target Gene Details

• Entrez Gene ID: 23409
• Gene Name: sirtuin 4
• Gene Aliases: SIR2L4
• Location: Chr.12:120292199-120313242 on Build GRCh38
• Assay Gene Location: Within Intron 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
SIRT4	XM_006719308.2			XP_006719371.1
	XM_006719309.3			XP_006719372.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv2673266	Chr.12:120294842 - 120299789 on Build GRCh38	Deletion	SIRT4
esv2763006	Chr.12:120293543 - 120312943 on Build GRCh38	Loss	SIRT4
nsv832530	Chr.12:120148265 - 120320372 on Build GRCh38	Loss	GCN1 PXN MIR4498 NME2P1 RNU4-2 RNU4-1 PXN-AS1 RPLP0 SIRT4
nsv560435	Chr.12:120257338 - 120331854 on Build GRCh38	Loss	PXN NME2P1 RNU4-2 RNU4-1 SIRT4 PLA2G1B

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

regulation of glutamine family amino acid metabolic process
chromatin silencing
protein ADP-ribosylation
glutamine metabolic process
cellular response to DNA damage stimulus
negative regulation of cardiac muscle cell apoptotic process
peptidyl-lysine deacetylation
negative regulation of fatty acid oxidation
negative regulation of insulin secretion
positive regulation of lipid biosynthetic process
cellular response to hypoxia
tricarboxylic acid metabolic process
negative regulation of protein processing involved in protein targeting to mitochondrion
regulation of pyruvate dehydrogenase activity

Function(s)

NAD+ ADP-ribosyltransferase activity
protein binding
zinc ion binding
NAD-dependent protein deacetylase activity
biotinidase activity
lipoamidase activity
NAD+ binding