Hs07060491_cn

• Gene Symbol: BDKRB2
• Assay Reference Genome Location: Chr.14:96224862 on build GRCh38
• Cytoband: 14q32.2

Target Gene Details

• Entrez Gene ID: 624
• Gene Name: bradykinin receptor B2
• Gene Aliases: B2R, BK-2, BK2, BKR2, BRB2
• Location: Chr.14:96204798-96244329 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
BDKRB2	NM_000623.3			NP_000614.1
	AK299316.1
	AK311049.1
	CR749338.1			CAH18192.1
	DA096163.1
	DC422332.1
	M88714.1			AAB02793.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1416	Chr.14:96217449 - 96252771 on Build GRCh38	Insertion	BDKRB2
nsv983853	Chr.14:96221559 - 96224948 on Build GRCh38	Duplication	BDKRB2
nsv1051786	Chr.14:96213058 - 96244781 on Build GRCh38	Gain	BDKRB2
esv3635418	Chr.14:96209831 - 96229962 on Build GRCh38	Gain	BDKRB2

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

G-protein coupled receptor

Gene Ontology Categories:

Process(es)

acute inflammatory response to antigenic stimulus
smooth muscle contraction
inflammatory response
cell surface receptor signaling pathway
transmembrane receptor protein tyrosine kinase signaling pathway
G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
blood circulation
negative regulation of cell proliferation
response to salt stress
regulation of vasoconstriction
negative regulation of peptidyl-serine phosphorylation
maintenance of blood-brain barrier
vasoconstriction
vasodilation
response to drug
regulation of vascular permeability
negative regulation of blood pressure
arachidonic acid secretion
cellular response to hypoxia
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator

Function(s)

protease binding
phosphatidylinositol phospholipase C activity
bradykinin receptor activity
protein binding
beta-2 adrenergic receptor binding
type 1 angiotensin receptor binding
protein heterodimerization activity