Hs07160726_cn

• Gene Symbol: SEMA6B
• Assay Reference Genome Location: Chr.19:4543359 on build GRCh38
• Cytoband: 19p13.3

Target Gene Details

• Entrez Gene ID: 10501
• Gene Name: semaphorin 6B
• Gene Aliases: SEM-SEMA-Y, SEMA-VIB, SEMAN, semaZ
• Location: Chr.19:4542588-4581484 on Build GRCh38
• Assay Gene Location: Within Exon 18

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
SEMA6B	NM_032108.3	17	3171	NP_115484.2
	XM_011527639.2	17	3238	XP_011525941.1
	XM_011527640.2	17	2981	XP_011525942.1
	AB022433.1	16	2947	BAB20669.1
	AB209278.1	16	2869	BAD92515.1
	AF216389.1			AAF87661.1
	AF293363.1			AAK16831.1
	AK300037.1
	AY358939.1	16	2927	AAQ89298.1
	BC142617.1	17	3114
	FR839673.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv828405	Chr.19:4540168 - 4546225 on Build GRCh38	Gain	SEMA6B
dgv614e199	Chr.19:4541633 - 4547580 on Build GRCh38	Deletion	SEMA6B
nsv953950	Chr.19:4540589 - 4723488 on Build GRCh38	Deletion	DPP9 DPP9-AS1 SEMA6B MYDGF TNFAIP8L1
nsv578444	Chr.19:4502189 - 4559634 on Build GRCh38	Gain	HDGFRP2 PLIN5 LRG1 SEMA6B PLIN4
nsv428361	Chr.19:4510042 - 4689189 on Build GRCh38	Loss	DPP9 PLIN5 LRG1 DPP9-AS1 SEMA6B MYDGF PLIN4 TNFAIP8L1

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

membrane-bound signaling molecule, intercellular signal molecule

Gene Ontology Categories:

Process(es)

neural crest cell migration
positive regulation of cell migration
negative regulation of axon extension involved in axon guidance
negative chemotaxis
semaphorin-plexin signaling pathway

Function(s)

semaphorin receptor binding
chemorepellent activity