Hs07167671_cn

• Gene Symbol: PTGIS
• Assay Reference Genome Location: Chr.20:49508916 on build GRCh38
• Cytoband: 20q13.13

Target Gene Details

• Entrez Gene ID: 5740
• Gene Name: prostaglandin I2 (prostacyclin) synthase
• Gene Aliases: CYP8, CYP8A1, PGIS, PTGI
• Location: Chr.20:49503874-49568170 on Build GRCh38
• Assay Gene Location: Within Intron 9

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PTGIS	NM_000961.3			NP_000952.1
	AF297048.1			AAG31781.1
	AF297049.1			AAG31782.1
	AF297050.1			AAG31783.1
	AF297051.1			AAG31784.1
	AF297052.1			AAG31785.1
	BC101809.1			AAI01810.1
	BC101811.1			AAI01812.1
	D38145.1			BAA07343.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1065852	Chr.20:49502654 - 49643666 on Build GRCh38	Loss	B4GALT5 PTGIS

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

prostaglandin biosynthetic process
icosanoid metabolic process
nicotinamide metabolic process
embryo implantation
cyclooxygenase pathway
negative regulation of NF-kappaB transcription factor activity
positive regulation of peroxisome proliferator activated receptor signaling pathway
negative regulation of nitric oxide biosynthetic process
positive regulation of angiogenesis
decidualization
negative regulation of inflammatory response
oxidation-reduction process
cellular response to interleukin-1
cellular response to interleukin-6
cellular response to hypoxia
apoptotic signaling pathway
positive regulation of execution phase of apoptosis

Function(s)

monooxygenase activity
iron ion binding
protein binding
prostaglandin-I synthase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
heme binding