Hs07172275_cn

• Gene Symbol: TRIB3
• Assay Reference Genome Location: Chr.20:392919 on build GRCh38
• Cytoband: 20p13

Target Gene Details

• Entrez Gene ID: 57761
• Gene Name: tribbles pseudokinase 3
• Gene Aliases: C20orf97, NIPK, SINK, SKIP3, TRB3
• Location: Chr.20:380629-397559 on Build GRCh38
• Assay Gene Location: Within Intron 5

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TRIB3	NM_001301188.1			NP_001288117.1
	NM_001301190.1			NP_001288119.1
	NM_001301193.1			NP_001288122.1
	NM_001301196.1			NP_001288125.1
	NM_001301201.1			NP_001288130.1
	NM_021158.4			NP_066981.2
	XM_017027989.1			XP_016883478.1
	AF250311.1			AAK58175.1
	AJ697936.1			CAG27047.1
	AK026945.1			BAB15597.1
	AK222837.1			BAD96557.1
	AK297546.1
	AY247738.1			AAP04407.1
	BC019363.1			AAH19363.1
	BC027484.1			AAH27484.1
	BG828172.1
	CR457366.1			CAG33647.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv3644951	Chr.20:385214 - 399104 on Build GRCh38	Loss	TRIB3
esv2057444	Chr.20:392894 - 393306 on Build GRCh38	Deletion	TRIB3
esv3644952	Chr.20:386013 - 1119183 on Build GRCh38	Gain	RBCK1 TRIB3 TCF15 TBC1D20 RSPO4 SLC52A3 ANGPT4 LOC105372493 SCRT2 PSMF1 SRXN1 CSNK2A1 FAM110A
nsv510777	Chr.20:366849 - 416704 on Build GRCh38	Deletion	RBCK1 TRIB3
nsv585170	Chr.20:380145 - 422066 on Build GRCh38	Loss	RBCK1 TRIB3
esv2657243	Chr.20:385360 - 399238 on Build GRCh38	Deletion	TRIB3
nsv519415	Chr.20:389506 - 396582 on Build GRCh38	Loss	TRIB3
dgv4219n100	Chr.20:80652 - 461103 on Build GRCh38	Gain	DEFB125 RBCK1 DEFB127 C20orf96 TRIB3 TBC1D20 LOC101929937 DEFB126 DEFB129 NRSN2-AS1 ZCCHC3 DEFB132 DEFB128 SOX12 NRSN2
esv3893263	Chr.20:216521 - 434561 on Build GRCh38	Loss	RBCK1 DEFB129 C20orf96 TRIB3 NRSN2-AS1 ZCCHC3 DEFB132 SOX12 NRSN2 LOC101929937

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

non-receptor serine/threonine protein kinase

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
protein phosphorylation
negative regulation of protein kinase activity
regulation of glucose transport
positive regulation of protein binding
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
cellular response to insulin stimulus
response to endoplasmic reticulum stress
regulation of MAP kinase activity
negative regulation of fat cell differentiation
negative regulation of fatty acid biosynthetic process
negative regulation of transcription, DNA-templated
positive regulation of ubiquitin-protein transferase activity
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

Function(s)

transcription corepressor activity
protein kinase inhibitor activity
protein binding
ATP binding
kinase activity
protein kinase binding
mitogen-activated protein kinase kinase binding
ubiquitin protein ligase binding
ubiquitin-protein transferase regulator activity