Hs07209681_cn

• Gene Symbol: TRIB3
• Assay Reference Genome Location: Chr.20:388502 on build GRCh38
• Cytoband: 20p13

Target Gene Details

• Entrez Gene ID: 57761
• Gene Name: tribbles pseudokinase 3
• Gene Aliases: C20orf97, NIPK, SINK, SKIP3, TRB3
• Location: Chr.20:380629-397559 on Build GRCh38
• Assay Gene Location: Within Intron 4

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TRIB3	NM_001301188.1			NP_001288117.1
	NM_001301190.1			NP_001288119.1
	NM_001301193.1			NP_001288122.1
	NM_001301196.1			NP_001288125.1
	NM_001301201.1			NP_001288130.1
	NM_021158.4			NP_066981.2
	XM_017027989.1			XP_016883478.1
	AF250311.1			AAK58175.1
	AJ697936.1			CAG27047.1
	AK026945.1			BAB15597.1
	AK222837.1			BAD96557.1
	AK297546.1
	AY247738.1			AAP04407.1
	BC019363.1			AAH19363.1
	BC027484.1			AAH27484.1
	BG828172.1
	CR457366.1			CAG33647.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv3644951	Chr.20:385214 - 399104 on Build GRCh38	Loss	TRIB3
esv3644952	Chr.20:386013 - 1119183 on Build GRCh38	Gain	TRIB3 RBCK1 SLC52A3 SCRT2 RSPO4 FAM110A TCF15 SRXN1 ANGPT4 CSNK2A1 TBC1D20 LOC105372493 PSMF1
nsv510777	Chr.20:366849 - 416704 on Build GRCh38	Deletion	TRIB3 RBCK1
nsv585170	Chr.20:380145 - 422066 on Build GRCh38	Loss	TRIB3 RBCK1
esv2657243	Chr.20:385360 - 399238 on Build GRCh38	Deletion	TRIB3
dgv4219n100	Chr.20:80652 - 461103 on Build GRCh38	Gain	TRIB3 RBCK1 DEFB129 ZCCHC3 C20orf96 NRSN2-AS1 DEFB127 DEFB125 NRSN2 DEFB128 LOC101929937 SOX12 TBC1D20 DEFB126 DEFB132
esv3893263	Chr.20:216521 - 434561 on Build GRCh38	Loss	TRIB3 RBCK1 DEFB129 ZCCHC3 C20orf96 LOC101929937 SOX12 NRSN2-AS1 NRSN2 DEFB132

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

non-receptor serine/threonine protein kinase

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
protein phosphorylation
negative regulation of protein kinase activity
regulation of glucose transport
positive regulation of protein binding
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
cellular response to insulin stimulus
response to endoplasmic reticulum stress
regulation of MAP kinase activity
negative regulation of fat cell differentiation
negative regulation of fatty acid biosynthetic process
negative regulation of transcription, DNA-templated
positive regulation of ubiquitin-protein transferase activity
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

Function(s)

transcription corepressor activity
protein kinase inhibitor activity
protein binding
ATP binding
kinase activity
protein kinase binding
mitogen-activated protein kinase kinase binding
ubiquitin protein ligase binding
ubiquitin-protein transferase regulator activity