Hs07421321_cn

• Gene Symbol: TPPP
• Assay Reference Genome Location: Chr.5:668834 on build GRCh38
• Cytoband: 5p15.33

Target Gene Details

• Entrez Gene ID: 11076
• Gene Name: tubulin polymerization promoting protein
• Gene Aliases: TPPP/p25, TPPP1, p24, p25, p25alpha
• Location: Chr.5:659862-730454 on Build GRCh38
• Assay Gene Location: Within Intron 7

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TPPP	NM_007030.2			NP_008961.1
	XM_005248237.3			XP_005248294.2
	XM_017008993.1			XP_016864482.1
	XM_017008994.1			XP_016864483.1
	AB017016.1			BAA36164.1
	AK054920.1
	AK098392.1
	AY319261.1			AAQ96657.1
	BC040496.1			AAH40496.1
	BC131506.1
	BC152382.1
	BT020035.1			AAV38838.1
	DB478250.2

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv3894107	Chr.5:81322 - 801057 on Build GRCh38	Gain	AHRR ZDHHC11 PLEKHG4B CCDC127 TPPP EXOC3-AS1 LOC100996325 ZDHHC11B LRRC14B CEP72 HRAT5 SLC9A3 SDHA PDCD6 PP7080 EXOC3 MIR4456 LOC100288152 LOC101929895
nsv596712	Chr.5:667132 - 674806 on Build GRCh38	Loss	TPPP LOC101929895
nsv1033593	Chr.5:609765 - 685633 on Build GRCh38	Gain	CEP72 TPPP LOC101929895 LOC100996325
nsv596703	Chr.5:539195 - 685633 on Build GRCh38	Gain	CEP72 TPPP LOC101929895 LOC100996325
nsv471627	Chr.5:609832 - 826405 on Build GRCh38	Gain+Loss	ZDHHC11B CEP72 ZDHHC11 TPPP LOC101929895 LOC100996325
esv3575808	Chr.5:668727 - 883706 on Build GRCh38	Gain	ZDHHC11B BRD9 ZDHHC11 TPPP LOC101929895
nsv1161198	Chr.5:654181 - 817735 on Build GRCh38	Duplication	ZDHHC11B CEP72 ZDHHC11 TPPP LOC101929895
esv3575804	Chr.5:588315 - 676732 on Build GRCh38	Gain	CEP72 TPPP LOC101929895 LOC100996325
dgv9497n54	Chr.5:668222 - 699075 on Build GRCh38	Loss	TPPP LOC101929895
dgv195e55	Chr.5:659490 - 823705 on Build GRCh38	Gain	ZDHHC11B CEP72 ZDHHC11 TPPP LOC101929895
dgv5521n100	Chr.5:568570 - 685633 on Build GRCh38	Gain	CEP72 TPPP LOC101929895 LOC100996325
nsv4675	Chr.5:658779 - 844631 on Build GRCh38	Deletion	ZDHHC11B CEP72 ZDHHC11 TPPP LOC101929895
nsv1032584	Chr.5:375290 - 809679 on Build GRCh38	Gain	AHRR ZDHHC11 TPPP EXOC3-AS1 LOC100996325 ZDHHC11B CEP72 SLC9A3 PP7080 EXOC3 MIR4456 LOC100288152 LOC101929895
esv2759316	Chr.5:620048 - 1161361 on Build GRCh38	Gain+Loss	ZDHHC11B LOC100506688 CEP72 NKD2 BRD9 ZDHHC11 MIR4635 TRIP13 TPPP LOC101929895 SLC12A7
dgv7n29	Chr.5:609831 - 820394 on Build GRCh38	Gain	ZDHHC11B CEP72 ZDHHC11 TPPP LOC101929895 LOC100996325
esv2439668	Chr.5:667371 - 668924 on Build GRCh38	Deletion	TPPP LOC101929895
nsv596629	Chr.5:457146 - 1468172 on Build GRCh38	Gain	MIR4635 TRIP13 TPPP CTD-3080P12.3 LOC100506688 SLC6A18 LPCAT1 EXOC3 MIR4456 MIR4457 BRD9 ZDHHC11 TERT SLC6A3 LINC01511 SLC12A7 LOC100996325 ZDHHC11B CEP72 NKD2 CLPTM1L SLC9A3 SLC6A19 PP7080 LOC100288152 LOC101929895
dgv5525n100	Chr.5:667323 - 852451 on Build GRCh38	Gain	ZDHHC11B ZDHHC11 TPPP LOC101929895
nsv509042	Chr.5:483833 - 720373 on Build GRCh38	Insertion	ZDHHC11B CEP72 SLC9A3 MIR4456 TPPP LOC101929895 LOC100996325
nsv950622	Chr.5:661486 - 693585 on Build GRCh38	Deletion	CEP72 TPPP LOC101929895
dgv922n67	Chr.5:662068 - 788975 on Build GRCh38	Gain	ZDHHC11B CEP72 TPPP LOC101929895
nsv596714	Chr.5:668277 - 880385 on Build GRCh38	Gain	ZDHHC11B BRD9 ZDHHC11 TPPP LOC101929895
dgv5522n100	Chr.5:625176 - 809679 on Build GRCh38	Gain	ZDHHC11B CEP72 ZDHHC11 TPPP LOC101929895
nsv596710	Chr.5:595755 - 729907 on Build GRCh38	Gain	ZDHHC11B CEP72 TPPP LOC101929895 LOC100996325
esv24225	Chr.5:666600 - 850826 on Build GRCh38	Gain+Loss	ZDHHC11B ZDHHC11 TPPP LOC101929895
dgv131e203	Chr.5:653466 - 874903 on Build GRCh38	Gain+Loss	ZDHHC11B CEP72 BRD9 ZDHHC11 TPPP LOC101929895
esv2752071	Chr.5:378298 - 699075 on Build GRCh38	Gain	CEP72 AHRR SLC9A3 PP7080 EXOC3 MIR4456 LOC100288152 TPPP LOC101929895 EXOC3-AS1 LOC100996325
dgv5524n100	Chr.5:659283 - 825526 on Build GRCh38	Gain	ZDHHC11B CEP72 ZDHHC11 TPPP LOC101929895
dgv5523n100	Chr.5:653454 - 790474 on Build GRCh38	Gain	ZDHHC11B CEP72 TPPP LOC101929895
nsv461894	Chr.5:593968 - 685633 on Build GRCh38	Gain	CEP72 TPPP LOC101929895 LOC100996325

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

non-motor microtubule binding protein

Gene Ontology Categories:

Process(es)

microtubule bundle formation
positive regulation of protein complex assembly
positive regulation of protein polymerization
microtubule polymerization

Function(s)

protein binding
microtubule binding
tubulin binding