Hs07545276_cn

• Gene Symbol: CYP2A7
• Assay Reference Genome Location: Chr.19:40882287 on build GRCh38
• Cytoband: 19q13.2

Target Gene Details

• Entrez Gene ID: 1549
• Gene Name: cytochrome P450 family 2 subfamily A member 7
• Gene Aliases: CPA7, CPAD, CYP2A, CYPIIA7, P450-IIA4
• Location: Chr.19:40875439-40885952 on Build GRCh38
• Assay Gene Location: Within Exon 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
CYP2A7	NM_000764.2	1	466	NP_000755.2
	NM_030589.2	1	466	NP_085079.2
	XM_017026383.1	1	3663	XP_016881872.1
	BC117165.1
	BC143325.1
	M33317.1			AAA52138.1
	U22029.1	1	466	AAB40520.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
dgv142n111	Chr.19:40833964 - 40888431 on Build GRCh38	Deletion	CYP2A6 CYP2A7
nsv1065886	Chr.19:40833952 - 40891756 on Build GRCh38	Loss	CYP2A6 CYP2G1P CYP2A7
esv2718569	Chr.19:40876567 - 40909361 on Build GRCh38	Deletion	CYP2G1P CYP2A7
esv2760509	Chr.19:40819099 - 40888431 on Build GRCh38	Gain+Loss	CYP2A6 CYP2A7
dgv522e201	Chr.19:40849715 - 40882494 on Build GRCh38	Deletion	CYP2A6 CYP2A7
nsv1056244	Chr.19:40823313 - 40891756 on Build GRCh38	Gain	CYP2A6 CYP2G1P CYP2A7
dgv643e199	Chr.19:40849810 - 40886591 on Build GRCh38	Deletion	CYP2A6 CYP2A7
nsv435697	Chr.19:40848417 - 40882223 on Build GRCh38	Deletion	CYP2A6 CYP2A7
esv2758762	Chr.19:40785722 - 41040163 on Build GRCh38	Gain+Loss	CYP2B6 CYP2A6 EGLN2 RAB4B-EGLN2 MIA-RAB4B RAB4B CYP2B7P CYP2G1P CYP2A7P1 CYP2A7 CYP2T1P
dgv6452n54	Chr.19:40875596 - 40886585 on Build GRCh38	Gain	CYP2A7
dgv1046e212	Chr.19:40839410 - 40886237 on Build GRCh38	Gain	CYP2A6 CYP2A7
nsv9729	Chr.19:40831900 - 40888502 on Build GRCh38	Loss	CYP2A6 CYP2A7
dgv6442n54	Chr.19:40843827 - 40887855 on Build GRCh38	Loss	CYP2A6 CYP2A7
nsv1160625	Chr.19:40851095 - 40886249 on Build GRCh38	Deletion	CYP2A7
esv3556401	Chr.19:40849778 - 40885095 on Build GRCh38	Deletion	CYP2A6 CYP2A7
esv21610	Chr.19:40831396 - 40887351 on Build GRCh38	Gain+Loss	CYP2A6 CYP2A7
nsv1066637	Chr.19:40803306 - 41091991 on Build GRCh38	Gain	CYP2B6 CYP2A6 EGLN2 RAB4B-EGLN2 CYP2B7P CYP2A13 CYP2G1P CYP2A7P1 CYP2A7 CYP2T1P
dgv1051e212	Chr.19:40854225 - 40889591 on Build GRCh38	Gain	CYP2A7
esv33053	Chr.19:40834724 - 40894730 on Build GRCh38	Gain	CYP2A6 CYP2G1P CYP2A7
dgv3539n100	Chr.19:40846466 - 40891756 on Build GRCh38	Loss	CYP2A6 CYP2G1P CYP2A7

More Information

Important Information

Individuals may carry null or extra alleles of the CYP2A7 pseudogene or CYP2A6/CYP2A7 hybrid alleles. Hs07545276_cn specifically targets CYP2A7 exon 1 sequences and will not amplify CYP2A6 but will amplify CYP2A6/CYP2A7 hybrid alleles carrying CYP2A7 exon 1 sequences (e.g. CYP2A6*12 contains CYP2A7 exons 1-2 and CYP2A6 exons 3-9).

Additional Information:

• Set Membership: Intragenic, Exonic, DGV Variation, Validated

Panther Classification:

Molecular Function -

oxidoreductase, oxygenase, metabolite interconversion enzyme

Gene Ontology Categories:

Process(es)

epoxygenase P450 pathway
oxidation-reduction process

Function(s)

iron ion binding
arachidonic acid epoxygenase activity
steroid hydroxylase activity
oxygen binding
heme binding
aromatase activity