Mm00736685_cn

• Gene Symbol: Jak2
• Assay Reference Genome Location: Chr.19:29271020 on build GRCm38
• Cytoband: 19C1

Target Gene Details

• Entrez Gene ID: 16452
• Gene Name: Janus kinase 2
• Gene Aliases: Fd17
• Location: Chr.19:29251776-29313080 on Build GRCm38
• Assay Gene Location: Within Intron 3

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
Jak2	NM_001048177.2			NP_001041642.1
	NM_008413.3			NP_032439.2
	AK087255.1
	BC054807.1			AAH54807.1
	BC059834.1			AAH59834.1
	BE981299.1
	L16956.1			AAB41327.1

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, Validated

Gene Ontology Categories:

Process(es)

activation of MAPKK activity
immune system process
protein phosphorylation
activation of cysteine-type endopeptidase activity involved in apoptotic process
response to oxidative stress
signal transduction
enzyme linked receptor protein signaling pathway
transmembrane receptor protein tyrosine kinase signaling pathway
G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
JAK-STAT cascade
tyrosine phosphorylation of STAT protein
STAT protein import into nucleus
positive regulation of cell proliferation
negative regulation of cell proliferation
intrinsic apoptotic signaling pathway in response to oxidative stress
hormone-mediated signaling pathway
negative regulation of cardiac muscle cell apoptotic process
positive regulation of cell-substrate adhesion
positive regulation of phosphatidylinositol 3-kinase signaling
phosphorylation
cell migration
chromatin modification
peptidyl-tyrosine phosphorylation
cytokine-mediated signaling pathway
negative regulation of cell-cell adhesion
myeloid cell differentiation
cell differentiation
regulation of cell adhesion
erythrocyte differentiation
positive regulation of cell migration
axon regeneration
mineralocorticoid receptor signaling pathway
positive regulation of insulin secretion
response to lipopolysaccharide
positive regulation of phosphoprotein phosphatase activity
positive regulation of interleukin-1 beta production
positive regulation of tumor necrosis factor production
positive regulation of protein import into nucleus, translocation
response to hydroperoxide
tumor necrosis factor-mediated signaling pathway
host programmed cell death induced by symbiont
response to tumor necrosis factor
histone H3-Y41 phosphorylation
intracellular signal transduction
interleukin-12-mediated signaling pathway
peptidyl-tyrosine autophosphorylation
tyrosine phosphorylation of Stat3 protein
tyrosine phosphorylation of Stat5 protein
tyrosine phosphorylation of Stat1 protein
positive regulation of tyrosine phosphorylation of Stat3 protein
positive regulation of tyrosine phosphorylation of Stat5 protein
activation of JAK2 kinase activity
positive regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of DNA binding
negative regulation of DNA binding
negative regulation of neuron apoptotic process
innate immune response
positive regulation of nitric oxide biosynthetic process
positive regulation of cell differentiation
negative regulation of heart contraction
positive regulation of transcription from RNA polymerase II promoter
response to antibiotic
protein autophosphorylation
platelet-derived growth factor receptor signaling pathway
regulation of inflammatory response
positive regulation of inflammatory response
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of cell activation
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of nitric-oxide synthase biosynthetic process
interferon-gamma-mediated signaling pathway
growth hormone receptor signaling pathway
JAK-STAT cascade involved in growth hormone signaling pathway
positive regulation of growth hormone receptor signaling pathway
mammary gland epithelium development
response to interleukin-12
cellular response to lipopolysaccharide
cellular response to dexamethasone stimulus
response to granulocyte macrophage colony-stimulating factor
extrinsic apoptotic signaling pathway
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
positive regulation of apoptotic signaling pathway

Function(s)

nucleotide binding
protein kinase activity
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
receptor binding
growth hormone receptor binding
interleukin-12 receptor binding
protein binding
ATP binding
protein C-terminus binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
protein kinase binding
heme binding
type 1 angiotensin receptor binding
acetylcholine receptor binding
histone kinase activity (H3-Y41 specific)
SH2 domain binding
histone binding
phosphatidylinositol 3-kinase binding
insulin receptor substrate binding
peptide hormone receptor binding