Hs00060795_cn

• Gene Symbol: STK11
• Assay Reference Genome Location: Chr.19:1206510 on build GRCh38
• Cytoband: 19p13.3

Target Gene Details

• Entrez Gene ID: 6794
• Gene Name: serine/threonine kinase 11
• Gene Aliases: LKB1, PJS, hLKB1
• Location: Chr.19:1205799-1228435 on Build GRCh38
• Assay Gene Location: Within Exon 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
STK11	NM_000455.4	1	712	NP_000446.1
	XM_005259617.2	1	222	XP_005259674.1
	XM_005259618.3	1	222	XP_005259675.1
	XM_011528209.1	1	222	XP_011526511.1
	AF217978.1	2	557	AAG17221.1
	BC007981.2	1	47	AAH07981.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1058677	Chr.19:1054061 - 1283189 on Build GRCh38	Loss	STK11 ATP5D CBARP GPX4 CIRBP-AS1 LOC102725180 ARHGAP45 ABCA7 EFNA2 C19orf24 CIRBP MIDN SBNO2 POLR2E
dgv136n111	Chr.19:1038223 - 1329640 on Build GRCh38	Deletion	STK11 ATP5D CBARP GPX4 CIRBP-AS1 LOC102725180 ARHGAP45 ABCA7 CNN2 EFNA2 C19orf24 CIRBP MIDN SBNO2 POLR2E
nsv9662	Chr.19:893394 - 1317740 on Build GRCh38	Gain	STK11 RNU6-9 ATP5D CBARP WDR18 TMEM259 ARID3A GPX4 CIRBP-AS1 KISS1R LOC102725180 ARHGAP45 ABCA7 CNN2 RNU6-2 EFNA2 C19orf24 CIRBP GRIN3B MIDN LOC105372235 SBNO2 POLR2E R3HDM4
nsv470104	Chr.19:1170446 - 1325151 on Build GRCh38	Loss	LOC102725180 STK11 EFNA2 ATP5D CBARP C19orf24 CIRBP MIDN SBNO2 CIRBP-AS1
nsv1160555	Chr.19:887275 - 1346084 on Build GRCh38	Deletion	STK11 RNU6-9 ATP5D CBARP WDR18 ARID3A CIRBP-AS1 KISS1R LOC102725180 ABCA7 CNN2 RNU6-2 EFNA2 GRIN3B LOC105372235 SBNO2 POLR2E TMEM259 GPX4 MED16 ARHGAP45 C19orf24 CIRBP MIDN R3HDM4
nsv953941	Chr.19:1205602 - 1322401 on Build GRCh38	Deletion	STK11 EFNA2 ATP5D CBARP C19orf24 CIRBP MIDN CIRBP-AS1
nsv470103	Chr.19:1086044 - 1325151 on Build GRCh38	Gain	STK11 ATP5D CBARP GPX4 CIRBP-AS1 LOC102725180 ARHGAP45 EFNA2 C19orf24 CIRBP MIDN SBNO2 POLR2E
esv2758743	Chr.19:951641 - 1544934 on Build GRCh38	Gain+Loss	PLK5 STK11 ATP5D CBARP WDR18 GAMT ARID3A CIRBP-AS1 LOC102725180 ABCA7 CNN2 PCSK4 RNU6-2 EFNA2 GRIN3B LOC105372235 SBNO2 POLR2E DAZAP1 RPS15 TMEM259 ADAMTSL5 GPX4 NDUFS7 C19orf25 ARHGAP45 REEP6 MUM1 C19orf24 CIRBP MIDN APC2

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Gene Ontology Categories:

Process(es)

regulation of cell growth
tissue homeostasis
vasculature development
protein phosphorylation
autophagy
cellular response to DNA damage stimulus
cell cycle arrest
spermatid development
axonogenesis
negative regulation of cell proliferation
response to ionizing radiation
positive regulation of autophagy
establishment of cell polarity
regulation of Wnt signaling pathway
negative regulation of cell growth
positive regulation of transforming growth factor beta receptor signaling pathway
activation of protein kinase activity
TCR signalosome assembly
glucose homeostasis
anoikis
positive thymic T cell selection
protein autophosphorylation
regulation of dendrite morphogenesis
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of axonogenesis
T cell receptor signaling pathway
negative regulation of lipid biosynthetic process
Golgi localization
regulation of protein kinase B signaling
canonical Wnt signaling pathway
negative regulation of epithelial cell proliferation involved in prostate gland development
cellular response to UV-B
positive regulation of protein serine/threonine kinase activity
intrinsic apoptotic signaling pathway by p53 class mediator
dendrite extension
positive regulation of protein localization to nucleus
regulation of signal transduction by p53 class mediator
negative regulation of TORC1 signaling

Function(s)

magnesium ion binding
p53 binding
protein serine/threonine kinase activity
protein binding
ATP binding
LRR domain binding
protein kinase activator activity