Hs00171593_cn

• Gene Symbol: APC2
• Assay Reference Genome Location: Chr.19:1455184 on build GRCh38
• Cytoband: 19p13.3

Target Gene Details

• Entrez Gene ID: 10297
• Gene Name: APC2, WNT signaling pathway regulator
• Gene Aliases: APCL
• Location: Chr.19:1446268-1473244 on Build GRCh38
• Assay Gene Location: Overlaps Intron 6 - Exon 7

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
APC2	NM_005883.2			NP_005874.1
	XM_005259475.2			XP_005259532.1
	XM_006722607.2			XP_006722670.1
	XM_006722608.3			XP_006722671.2
	XM_006722609.3			XP_006722672.1
	XM_006722610.3			XP_006722673.2
	AB012162.1			BAA34611.1
	AF110334.1			AAD28183.1
	AF128222.1			AAF01784.1
	AJ012652.1			CAB61207.1
	AL078616.1
	BC032573.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv32942	Chr.19:1320268 - 1999205 on Build GRCh38	Gain+Loss	ATP8B3 CSNK1G2-AS1 APC2 SCAMP4 LOC100288123 ONECUT3 ABHD17A MBD3 DAZAP1 UQCR11 MIR1909 ADAT3 TCF3 GAMT MUM1 MEX3D PCSK4 NDUFS7 CSNK1G2 RPS15 BTBD2 REEP6 KLF16 C19orf25 PLK5 REXO1 ADAMTSL5
nsv578279	Chr.19:1413575 - 1530061 on Build GRCh38	Gain	REEP6 APC2 C19orf25 PLK5 PCSK4 DAZAP1 ADAMTSL5 RPS15
nsv833705	Chr.19:1380125 - 1544934 on Build GRCh38	Loss	REEP6 APC2 C19orf25 PLK5 PCSK4 NDUFS7 DAZAP1 ADAMTSL5 RPS15 GAMT
esv2758743	Chr.19:951641 - 1544934 on Build GRCh38	Gain+Loss	APC2 STK11 GPX4 SBNO2 ATP5D LOC102725180 CIRBP-AS1 WDR18 CBARP ABCA7 DAZAP1 MIDN C19orf24 GRIN3B CIRBP GAMT MUM1 PCSK4 NDUFS7 LOC105372235 ARHGAP45 RPS15 CNN2 POLR2E REEP6 ARID3A C19orf25 PLK5 TMEM259 ADAMTSL5 RNU6-2 EFNA2
nsv953942	Chr.19:1371602 - 2057401 on Build GRCh38	Deletion	ATP8B3 CSNK1G2-AS1 APC2 SCAMP4 LOC100288123 ONECUT3 ABHD17A MBD3 DAZAP1 UQCR11 MIR1909 ADAT3 TCF3 GAMT MUM1 MEX3D PCSK4 NDUFS7 CSNK1G2 RPS15 BTBD2 REEP6 KLF16 C19orf25 PLK5 MKNK2 REXO1 ADAMTSL5
nsv470105	Chr.19:1444420 - 1526614 on Build GRCh38	Gain	REEP6 APC2 C19orf25 PLK5 PCSK4 ADAMTSL5

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

cell fate specification
negative regulation of microtubule depolymerization
pattern specification process
cell proliferation
Wnt signaling pathway
cell migration
negative regulation of catenin import into nucleus
regulation of cell differentiation
positive regulation of protein catabolic process
negative regulation of canonical Wnt signaling pathway

Function(s)

protein binding
beta-catenin binding
microtubule binding
gamma-catenin binding