Hs00173864_cn

• Gene Symbol: DGCR8
• Assay Reference Genome Location: Chr.22:20086332 on build GRCh38
• Cytoband: 22q11.21

Target Gene Details

• Entrez Gene ID: 54487
• Gene Name: DGCR8 microprocessor complex subunit
• Gene Aliases: C22orf12, DGCRK6, Gy1, pasha
• Location: Chr.22:20080232-20111877 on Build GRCh38
• Assay Gene Location: Within Exon 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
DGCR8	NM_001190326.1	2	798	NP_001177255.1
	NM_022720.6	2	798	NP_073557.3
	AF165527.1	1	459	AAF82263.1
	AK313357.1	2	749
	BC009984.2	2	719	AAH09984.1
	BC078147.1	1	512	AAH78147.1
	BQ227899.1
	CR456356.1	1	456	CAG30242.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
dgv726n67	Chr.22:20070444 - 20324465 on Build GRCh38	Gain	MIR3618 CCDC188 LINC00896 LOC440792 DGCR8 DGCR6L RTN4R MIR1286 MIR1306 LOC284865 TRMT2A ZDHHC8 RANBP1 MIR6816
esv3647284	Chr.22:19985583 - 20137122 on Build GRCh38	Gain	MIR3618 TRMT2A ZDHHC8 RANBP1 TANGO2 DGCR8 MIR6816 MIR185 MIR1306 ARVCF
esv3893434	Chr.22:19470889 - 20343372 on Build GRCh38	Gain	MIR3618 COMT DGCR6L UFD1L CDC45 MIR1306 CLDN5 SEPT5 RANBP1 TANGO2 LOC101927859 CCDC188 LINC00896 LOC440792 DGCR8 TXNRD2 RTN4R MIR1286 GNB1L SEPT5-GP1BB LOC284865 C22orf29 TRMT2A TBX1 GP1BB ZDHHC8 MIR6816 MIR4761 LINC00895 MIR185 ARVCF
esv2758825	Chr.22:20038970 - 20321924 on Build GRCh38	Loss	MIR3618 CCDC188 LINC00896 LOC440792 DGCR8 DGCR6L RTN4R MIR1286 MIR1306 LOC284865 TRMT2A ZDHHC8 RANBP1 TANGO2 MIR6816
nsv828939	Chr.22:19696032 - 20324465 on Build GRCh38	Loss	MIR3618 COMT DGCR6L MIR1306 SEPT5 RANBP1 TANGO2 CCDC188 LINC00896 LOC440792 DGCR8 TXNRD2 RTN4R MIR1286 GNB1L SEPT5-GP1BB LOC284865 C22orf29 TRMT2A TBX1 GP1BB ZDHHC8 MIR6816 MIR4761 MIR185 ARVCF
nsv828938	Chr.22:19691069 - 20324465 on Build GRCh38	Gain	MIR3618 COMT DGCR6L MIR1306 SEPT5 RANBP1 TANGO2 CCDC188 LINC00896 LOC440792 DGCR8 TXNRD2 RTN4R MIR1286 GNB1L SEPT5-GP1BB LOC284865 C22orf29 TRMT2A TBX1 GP1BB ZDHHC8 MIR6816 MIR4761 MIR185 ARVCF
dgv4480n100	Chr.22:20069620 - 20262667 on Build GRCh38	Gain	MIR3618 TRMT2A CCDC188 LINC00896 ZDHHC8 RANBP1 DGCR8 RTN4R MIR6816 MIR1286 MIR1306 LOC284865
nsv471183	Chr.22:20018517 - 20319470 on Build GRCh38	Loss	MIR3618 CCDC188 LINC00896 LOC440792 DGCR8 DGCR6L RTN4R MIR1286 MIR1306 LOC284865 TRMT2A ZDHHC8 RANBP1 TANGO2 MIR6816 MIR185
nsv953027	Chr.22:20085378 - 20303977 on Build GRCh38	Deletion	MIR3618 CCDC188 LINC00896 LOC440792 DGCR8 RTN4R MIR1286 MIR1306 LOC284865 TRMT2A ZDHHC8 RANBP1 MIR6816
nsv834133	Chr.22:20029363 - 20176708 on Build GRCh38	Loss	MIR3618 TRMT2A CCDC188 ZDHHC8 RANBP1 TANGO2 DGCR8 MIR6816 MIR185 MIR1306
dgv7983n54	Chr.22:19762002 - 20321870 on Build GRCh38	Gain	MIR3618 CCDC188 LINC00896 LOC440792 COMT DGCR8 TXNRD2 DGCR6L RTN4R MIR1286 GNB1L MIR1306 LOC284865 C22orf29 TRMT2A TBX1 ZDHHC8 RANBP1 TANGO2 MIR6816 MIR4761 MIR185 ARVCF

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

RNA metabolism protein, RNA processing factor, nucleic acid metabolism protein, scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

gene silencing by RNA
primary miRNA processing
regulation of stem cell proliferation
RNA phosphodiester bond hydrolysis, endonucleolytic

Function(s)

double-stranded RNA binding
ribonuclease III activity
protein binding
heme binding
protein homodimerization activity
metal ion binding
primary miRNA binding