Hs00251194_cn

• Gene Symbol: PARP10
• Assay Reference Genome Location: Chr.8:143977594 on build GRCh38
• Cytoband: 8q24.3

Target Gene Details

• Entrez Gene ID: 84875
• Gene Name: poly(ADP-ribose) polymerase family member 10
• Gene Aliases: ARTD10
• Location: Chr.8:143977152-143986471 on Build GRCh38
• Assay Gene Location: Within Exon 10

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PARP10	NM_001317895.1	10	3204	NP_001304824.1
	NM_032789.4	11	3080	NP_116178.2
	NR_134234.1	11	2935
	XM_011517336.2	11	3020	XP_011515638.1
	AK027370.1	11	3037	BAB55067.1
	AK075250.1	7	1767	BAC11498.1
	AK124017.1	4	1738
	AK128537.1	12	2895
	AK129821.1	7	1558
	AK222914.1	11	3063	BAD96634.1
	AK303317.1	10	3129
	BC014229.2	4	1064	AAH14229.2
	BC019030.2	7	1900	AAH19030.2
	BC132961.1	11	3031
	BC136542.1	11	3031
	BU625932.1	1	460

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv6445	Chr.8:143961415 - 143994522 on Build GRCh38	Insertion	PLEC PARP10 GRINA
nsv470249	Chr.8:143889098 - 144519234 on Build GRCh38	Loss	FOXH1 GPAA1 SMPD5 CYHR1 MROH1 VPS28 RECQL4 MIR6846 TMEM249 GRINA MIR6849 FBXL6 LOC101928953 MAF1 SLC52A2 PPP1R16A LRRC14 HSF1 SPATC1 CYC1 MIR661 PARP10 SHARPIN MIR939 GPT ADCK5 TONSL OPLAH BOP1 DGAT1 MIR1234 PLEC TONSL-AS1 HGH1 SCRT1 SCX EXOSC4 MIR6847 MFSD3 WDR97 LOC101928902 SLC39A4 MIR7112 MIR6848 MIR6893 KIFC2 CPSF1
nsv515809	Chr.8:143904439 - 144519234 on Build GRCh38	Gain+Loss	FOXH1 GPAA1 SMPD5 CYHR1 MROH1 VPS28 RECQL4 MIR6846 TMEM249 GRINA MIR6849 FBXL6 LOC101928953 MAF1 SLC52A2 PPP1R16A LRRC14 HSF1 SPATC1 CYC1 MIR661 PARP10 SHARPIN MIR939 GPT ADCK5 TONSL OPLAH BOP1 DGAT1 MIR1234 PLEC TONSL-AS1 HGH1 SCRT1 SCX EXOSC4 MIR6847 MFSD3 WDR97 LOC101928902 SLC39A4 MIR7112 MIR6848 MIR6893 KIFC2 CPSF1
nsv612914	Chr.8:143972494 - 144120626 on Build GRCh38	Loss	GPAA1 SMPD5 PLEC MIR6846 GRINA MAF1 EXOSC4 MIR6847 SPATC1 WDR97 CYC1 PARP10 SHARPIN OPLAH
dgv12431n54	Chr.8:143845100 - 144161320 on Build GRCh38	Loss	GPAA1 SMPD5 PLEC MROH1 EPPK1 HGH1 MIR6846 GRINA MAF1 EXOSC4 MIR6847 SPATC1 WDR97 CYC1 MIR661 PARP10 SHARPIN OPLAH
nsv950015	Chr.8:143866633 - 144125597 on Build GRCh38	Deletion	GPAA1 SMPD5 PLEC EPPK1 MIR6846 GRINA MAF1 EXOSC4 MIR6847 SPATC1 WDR97 CYC1 MIR661 PARP10 SHARPIN OPLAH
nsv1161815	Chr.8:143775169 - 144080674 on Build GRCh38	Deletion	MIR6845 SMPD5 PLEC EPPK1 SCRIB NRBP2 MIR6846 MIR937 GRINA EXOSC4 MIR6847 SPATC1 LOC642574 MIR661 PARP10 PUF60 OPLAH
nsv470250	Chr.8:143917934 - 144097007 on Build GRCh38	Gain	GPAA1 EXOSC4 MIR6847 SMPD5 SPATC1 PLEC CYC1 MIR661 PARP10 MIR6846 GRINA OPLAH
dgv12433n54	Chr.8:143902404 - 144120626 on Build GRCh38	Gain	GPAA1 SMPD5 PLEC MIR6846 GRINA MAF1 EXOSC4 MIR6847 SPATC1 WDR97 CYC1 MIR661 PARP10 SHARPIN OPLAH
nsv612906	Chr.8:143917935 - 144090784 on Build GRCh38	Loss	GPAA1 EXOSC4 MIR6847 SMPD5 SPATC1 PLEC MIR661 PARP10 MIR6846 GRINA OPLAH

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Gene Ontology Categories:

Process(es)

protein ADP-ribosylation
negative regulation of gene expression
regulation of chromatin assembly
negative regulation of NF-kappaB transcription factor activity
negative regulation of protein import into nucleus, translocation
negative regulation of viral genome replication
negative regulation of fibroblast proliferation
protein poly-ADP-ribosylation
protein auto-ADP-ribosylation
negative regulation of protein K63-linked ubiquitination

Function(s)

NAD+ ADP-ribosyltransferase activity
protein binding
K63-linked polyubiquitin binding