Hs00287182_cn

• Gene Symbol: PARP10
• Assay Reference Genome Location: Chr.8:143978078 on build GRCh38
• Cytoband: 8q24.3

Target Gene Details

• Entrez Gene ID: 84875
• Gene Name: poly(ADP-ribose) polymerase family member 10
• Gene Aliases: ARTD10
• Location: Chr.8:143977152-143986471 on Build GRCh38
• Assay Gene Location: Overlaps Intron 8 - Exon 9

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PARP10	NM_001317895.1			NP_001304824.1
	NM_032789.4			NP_116178.2
	NR_134234.1
	XM_011517336.2			XP_011515638.1
	AK027370.1			BAB55067.1
	AK075250.1			BAC11498.1
	AK124017.1
	AK128537.1
	AK129821.1
	AK222914.1			BAD96634.1
	AK303317.1
	BC014229.2			AAH14229.2
	BC019030.2			AAH19030.2
	BC132961.1
	BC136542.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv6445	Chr.8:143961415 - 143994522 on Build GRCh38	Insertion	PARP10 GRINA PLEC
nsv470249	Chr.8:143889098 - 144519234 on Build GRCh38	Loss	LOC101928902 SLC52A2 BOP1 GPT SHARPIN ADCK5 EXOSC4 OPLAH LOC101928953 PARP10 MIR6848 SLC39A4 MROH1 PPP1R16A MIR6847 GPAA1 FOXH1 LRRC14 TONSL TONSL-AS1 RECQL4 SPATC1 FBXL6 VPS28 CPSF1 DGAT1 PLEC MIR6846 KIFC2 CYC1 CYHR1 MIR6893 MIR7112 MIR939 GRINA MIR1234 SCRT1 SMPD5 MFSD3 MIR661 SCX MAF1 MIR6849 HSF1 WDR97 TMEM249 HGH1
nsv515809	Chr.8:143904439 - 144519234 on Build GRCh38	Gain+Loss	LOC101928902 SLC52A2 BOP1 GPT SHARPIN ADCK5 EXOSC4 OPLAH LOC101928953 PARP10 MIR6848 SLC39A4 MROH1 PPP1R16A MIR6847 GPAA1 FOXH1 LRRC14 TONSL TONSL-AS1 RECQL4 SPATC1 FBXL6 VPS28 CPSF1 DGAT1 PLEC MIR6846 KIFC2 CYC1 CYHR1 MIR6893 MIR7112 MIR939 GRINA MIR1234 SCRT1 SMPD5 MFSD3 MIR661 SCX MAF1 MIR6849 HSF1 WDR97 TMEM249 HGH1
nsv612914	Chr.8:143972494 - 144120626 on Build GRCh38	Loss	SPATC1 SHARPIN EXOSC4 PLEC MIR6846 OPLAH PARP10 CYC1 GRINA SMPD5 MAF1 MIR6847 GPAA1 WDR97
dgv12431n54	Chr.8:143845100 - 144161320 on Build GRCh38	Loss	EPPK1 SPATC1 SHARPIN EXOSC4 PLEC MIR6846 OPLAH PARP10 CYC1 GRINA MROH1 SMPD5 MIR661 MAF1 MIR6847 GPAA1 WDR97 HGH1
nsv950015	Chr.8:143866633 - 144125597 on Build GRCh38	Deletion	EPPK1 SPATC1 SHARPIN EXOSC4 PLEC MIR6846 OPLAH PARP10 CYC1 GRINA SMPD5 MIR661 MAF1 MIR6847 GPAA1 WDR97
nsv1161815	Chr.8:143775169 - 144080674 on Build GRCh38	Deletion	EPPK1 SPATC1 MIR937 EXOSC4 PLEC MIR6846 OPLAH PARP10 LOC642574 GRINA SMPD5 NRBP2 SCRIB MIR6845 MIR661 MIR6847 PUF60
nsv470250	Chr.8:143917934 - 144097007 on Build GRCh38	Gain	PARP10 CYC1 GRINA SMPD5 SPATC1 MIR661 MIR6847 GPAA1 EXOSC4 PLEC MIR6846 OPLAH
dgv12433n54	Chr.8:143902404 - 144120626 on Build GRCh38	Gain	SPATC1 SHARPIN EXOSC4 PLEC MIR6846 OPLAH PARP10 CYC1 GRINA SMPD5 MIR661 MAF1 MIR6847 GPAA1 WDR97
nsv612906	Chr.8:143917935 - 144090784 on Build GRCh38	Loss	PARP10 GRINA SMPD5 SPATC1 MIR661 MIR6847 GPAA1 EXOSC4 PLEC MIR6846 OPLAH

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

protein ADP-ribosylation
negative regulation of gene expression
regulation of chromatin assembly
negative regulation of NF-kappaB transcription factor activity
negative regulation of protein import into nucleus, translocation
negative regulation of viral genome replication
negative regulation of fibroblast proliferation
protein poly-ADP-ribosylation
protein auto-ADP-ribosylation
negative regulation of protein K63-linked ubiquitination

Function(s)

NAD+ ADP-ribosyltransferase activity
protein binding
K63-linked polyubiquitin binding