Hs00365713_cn

• Gene Symbol: PARP10
• Assay Reference Genome Location: Chr.8:143982941 on build GRCh38
• Cytoband: 8q24.3

Target Gene Details

• Entrez Gene ID: 84875
• Gene Name: poly(ADP-ribose) polymerase family member 10
• Gene Aliases: ARTD10
• Location: Chr.8:143977152-143986471 on Build GRCh38
• Assay Gene Location: Overlaps Intron 8 - Exon 8

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PARP10	NM_001317895.1			NP_001304824.1
	NM_032789.4			NP_116178.2
	NR_134234.1
	XM_011517336.2			XP_011515638.1
	AK027370.1			BAB55067.1
	AK075250.1			BAC11498.1
	AK124017.1
	AK128537.1
	AK129821.1
	AK222914.1			BAD96634.1
	AK303317.1
	BC014229.2			AAH14229.2
	BC019030.2			AAH19030.2
	BC132961.1
	BC136542.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv6445	Chr.8:143961415 - 143994522 on Build GRCh38	Insertion	GRINA PARP10 PLEC
nsv470249	Chr.8:143889098 - 144519234 on Build GRCh38	Loss	SLC39A4 MAF1 PARP10 RECQL4 GPT CYC1 SCX MFSD3 MIR6846 SHARPIN MIR6849 MIR939 KIFC2 WDR97 OPLAH TONSL LOC101928902 MROH1 GPAA1 TMEM249 CYHR1 HSF1 SPATC1 BOP1 FBXL6 PPP1R16A MIR1234 SLC52A2 SMPD5 PLEC MIR6848 SCRT1 MIR7112 LRRC14 CPSF1 MIR6893 LOC101928953 GRINA MIR661 DGAT1 ADCK5 EXOSC4 HGH1 VPS28 TONSL-AS1 MIR6847 FOXH1
nsv515809	Chr.8:143904439 - 144519234 on Build GRCh38	Gain+Loss	SLC39A4 MAF1 PARP10 RECQL4 GPT CYC1 SCX MFSD3 MIR6846 SHARPIN MIR6849 MIR939 KIFC2 WDR97 OPLAH TONSL LOC101928902 MROH1 GPAA1 TMEM249 CYHR1 HSF1 SPATC1 BOP1 FBXL6 PPP1R16A MIR1234 SLC52A2 SMPD5 PLEC MIR6848 SCRT1 MIR7112 LRRC14 CPSF1 MIR6893 LOC101928953 GRINA MIR661 DGAT1 ADCK5 EXOSC4 HGH1 VPS28 TONSL-AS1 MIR6847 FOXH1
nsv612914	Chr.8:143972494 - 144120626 on Build GRCh38	Loss	MAF1 PARP10 SPATC1 CYC1 MIR6846 SMPD5 PLEC SHARPIN GRINA WDR97 OPLAH EXOSC4 GPAA1 MIR6847
dgv12431n54	Chr.8:143845100 - 144161320 on Build GRCh38	Loss	MAF1 PARP10 SPATC1 CYC1 MIR6846 EPPK1 SMPD5 PLEC SHARPIN GRINA MIR661 WDR97 OPLAH MROH1 EXOSC4 GPAA1 HGH1 MIR6847
nsv950015	Chr.8:143866633 - 144125597 on Build GRCh38	Deletion	MAF1 PARP10 SPATC1 CYC1 MIR6846 EPPK1 SMPD5 PLEC SHARPIN GRINA MIR661 WDR97 OPLAH EXOSC4 GPAA1 MIR6847
nsv1161815	Chr.8:143775169 - 144080674 on Build GRCh38	Deletion	MIR937 PARP10 SPATC1 MIR6845 MIR6846 EPPK1 SMPD5 PLEC NRBP2 GRINA MIR661 OPLAH LOC642574 EXOSC4 SCRIB PUF60 MIR6847
nsv470250	Chr.8:143917934 - 144097007 on Build GRCh38	Gain	GRINA MIR661 PARP10 SPATC1 OPLAH CYC1 EXOSC4 GPAA1 MIR6846 SMPD5 PLEC MIR6847
dgv12433n54	Chr.8:143902404 - 144120626 on Build GRCh38	Gain	MAF1 PARP10 SPATC1 CYC1 MIR6846 SMPD5 PLEC SHARPIN GRINA MIR661 WDR97 OPLAH EXOSC4 GPAA1 MIR6847
nsv612906	Chr.8:143917935 - 144090784 on Build GRCh38	Loss	GRINA MIR661 PARP10 SPATC1 OPLAH EXOSC4 GPAA1 MIR6846 SMPD5 PLEC MIR6847

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

protein ADP-ribosylation
negative regulation of gene expression
regulation of chromatin assembly
negative regulation of NF-kappaB transcription factor activity
negative regulation of protein import into nucleus, translocation
negative regulation of viral genome replication
negative regulation of fibroblast proliferation
protein poly-ADP-ribosylation
protein auto-ADP-ribosylation
negative regulation of protein K63-linked ubiquitination

Function(s)

NAD+ ADP-ribosyltransferase activity
protein binding
K63-linked polyubiquitin binding