Hs00474721_cn

• Gene Symbol: ADAMTS3
• Assay Reference Genome Location: Chr.4:72282870 on build GRCh38
• Cytoband: 4q13.3

Target Gene Details

• Entrez Gene ID: 9508
• Gene Name: ADAM metallopeptidase with thrombospondin type 1 motif 3
• Gene Aliases: ADAMTS-4
• Location: Chr.4:72280969-72568799 on Build GRCh38
• Assay Gene Location: Within Exon 24

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
ADAMTS3	NM_014243.2	22	3921	NP_055058.2
	XM_011532421.2	22	3953	XP_011530723.1
	XM_011532422.2	22	4452	XP_011530724.1
	AB002364.1	22	3873	BAA20821.1
	BC016451.1	5	1361	AAH16451.1
	BC130287.1	22	3918
	BC132735.1	22	3918

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv829968	Chr.4:72147632 - 72286232 on Build GRCh38	Gain	ADAMTS3 NPFFR2

More Information

Additional Information:

For this assay, SNP(s) [rs114446523] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

metalloprotease

Gene Ontology Categories:

Process(es)

vascular endothelial growth factor production
protein processing
collagen fibril organization
collagen catabolic process
collagen biosynthetic process
extracellular fibril organization
positive regulation of vascular endothelial growth factor signaling pathway

Function(s)

endopeptidase activity
metalloendopeptidase activity
protein binding
heparin binding
zinc ion binding