Hs00488664_cn

• Gene Symbol: IL2RB
• Assay Reference Genome Location: Chr.22:37128134 on build GRCh38
• Cytoband: 22q12.3

Target Gene Details

• Entrez Gene ID: 3560
• Gene Name: interleukin 2 receptor subunit beta
• Gene Aliases: CD122, IL15RB, P70-75
• Location: Chr.22:37125838-37149922 on Build GRCh38
• Assay Gene Location: Within Exon 10

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
IL2RB	NM_000878.3	10	1749	NP_000869.1
	AK312860.1
	BC025691.1	10	1732	AAH25691.1
	CR456506.1	9	1637	CAG30392.1
	M26062.1	10	1749	AAA59143.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv829203	Chr.22:36998126 - 37773322 on Build GRCh38	Loss	KCTD17 MPST SH3BP1 RAC2 TRIOBP SSTR3 LOC102724378 TMPRSS6 LGALS2 CDC42EP1 NOL12 TST LGALS1 C1QTNF6 GGA1 PDXP CYTH4 MFNG ELFN2 IL2RB LOC100506271 CARD10 TEX33 LOC101927051
nsv834187	Chr.22:36965603 - 37163260 on Build GRCh38	Loss	LL22NC01-81G9.3 TST KCTD17 MPST IL2RB TMPRSS6 TEX33
esv34015	Chr.22:36966049 - 37189804 on Build GRCh38	Loss	LL22NC01-81G9.3 TST C1QTNF6 KCTD17 MPST IL2RB TMPRSS6 TEX33
nsv459882	Chr.22:36967923 - 37161398 on Build GRCh38	Gain	LL22NC01-81G9.3 TST KCTD17 MPST IL2RB TMPRSS6 TEX33

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

transmembrane signal receptor

Gene Ontology Categories:

Process(es)

MAPK cascade
protein complex assembly
signal transduction
viral process
cytokine-mediated signaling pathway
natural killer cell activation
interleukin-2-mediated signaling pathway
negative regulation of apoptotic process
positive regulation of GTPase activity

Function(s)

interleukin-2 receptor activity
Ras guanyl-nucleotide exchange factor activity
protein binding
interleukin-2 binding