Hs00515697_cn

• Gene Symbol: KMT2B
• Assay Reference Genome Location: Chr.19:35727907 on build GRCh38
• Cytoband: 19q13.12

Target Gene Details

• Entrez Gene ID: 9757
• Gene Name: lysine methyltransferase 2B
• Gene Aliases: CXXC10, HRX2, MLL1B, MLL2, MLL4, TRX2, WBP-7, WBP7
• Location: Chr.19:35717818-35738880 on Build GRCh38
• Assay Gene Location: Overlaps Intron 17 - Exon 18

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
KMT2B	NM_014727.2			NP_055542.1
	XM_011527561.2			XP_011525863.2
	XM_011527562.2			XP_011525864.1
	XM_017027544.1			XP_016883033.1
	XM_017027545.1			XP_016883034.1
	XM_017027546.1			XP_016883035.1
	AB002302.3			BAA20763.3
	AF104918.1			AAD17932.1
	AF186605.1			AAD56420.1
	AJ007041.1			CAB45385.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv579422	Chr.19:35665686 - 35774606 on Build GRCh38	Loss	PROSER3 UPK1A-AS1 KMT2B IGFLR1 PSENEN HSPB6 U2AF1L4 ZBTB32 UPK1A LIN37

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

histone modifying enzyme

Gene Ontology Categories:

Process(es)

ovarian follicle development
transcription, DNA-templated
memory
oocyte differentiation
gene silencing
ovulation
chromatin-mediated maintenance of transcription
histone H3-K4 methylation
regulation of histone H3-K4 methylation
histone H3-K4 trimethylation

Function(s)

DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
zinc ion binding
histone-lysine N-methyltransferase activity
histone methyltransferase activity (H3-K4 specific)