Hs00569749_cn

• Gene Symbol: METTL3
• Assay Reference Genome Location: Chr.14:21501858 on build GRCh38
• Cytoband: 14q11.2

Target Gene Details

• Entrez Gene ID: 56339
• Gene Name: methyltransferase like 3
• Gene Aliases: IME4, M6A, MT-A70, Spo8
• Location: Chr.14:21498131-21511375 on Build GRCh38
• Assay Gene Location: Overlaps Intron 3 - Exon 4

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
METTL3	NM_019852.4			NP_062826.2
	XM_006720206.3			XP_006720269.1
	XM_011536968.1			XP_011535270.1
	AK000222.1
	AK093509.1
	AK097873.1
	AK098655.1
	AK300289.1
	AK304251.1
	AK304570.1
	BC001650.2			AAH01650.1
	BC003031.1			AAH03031.1
	BC052244.1			AAH52244.1
	BX247964.1			CAD62303.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv3633718	Chr.14:21495207 - 21527525 on Build GRCh38	Gain	SALL2 TOX4 METTL3
nsv85879	Chr.14:21497546 - 21506056 on Build GRCh38	Deletion	TOX4 METTL3
esv2422459	Chr.14:21463465 - 21701280 on Build GRCh38	Duplication	OR4E1 SALL2 OR4E2 OR10G3 TOX4 METTL3 OR10G2 RAB2B
esv3633716	Chr.14:21455908 - 21564274 on Build GRCh38	Gain	SALL2 TOX4 METTL3 RAB2B

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

RNA metabolism protein, RNA methyltransferase, nucleic acid metabolism protein

Gene Ontology Categories:

Process(es)

mRNA splicing, via spliceosome
RNA methylation
adenosine to inosine editing
mRNA processing
circadian rhythm
gene expression
stem cell population maintenance
primary miRNA processing
mRNA destabilization
mRNA methylation
positive regulation of cap-independent translational initiation
primary miRNA methylation

Function(s)

mRNA binding
RNA methyltransferase activity
mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity
protein heterodimerization activity
S-adenosyl-L-methionine binding