Hs00641142_cn

• Gene Symbol: MED12L
• Assay Reference Genome Location: Chr.3:151357295 on build GRCh38
• Cytoband: 3q25.1

Target Gene Details

• Entrez Gene ID: 116931
• Gene Name: mediator complex subunit 12 like
• Gene Aliases: NOPAR, TNRC11L, TRALP, TRALPUSH
• Location: Chr.3:151085665-151436677 on Build GRCh38
• Assay Gene Location: Within Exon 21

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
MED12L	NM_053002.5	18	2768	NP_443728.3
	XM_006713487.3	20	3145	XP_006713550.1
	XM_011512390.2	19	3040	XP_011510692.1
	XM_011512394.2	20	3145	XP_011510696.1
	XM_011512399.2	20	3145	XP_011510701.1
	XM_017005676.1	20	3145	XP_016861165.1
	XM_017005677.1	20	3145	XP_016861166.1
	XM_017005678.1	20	3145	XP_016861167.1
	XM_017005679.1	19	2875	XP_016861168.1
	XM_017005680.1	18	2863	XP_016861169.1
	XM_017005681.1	5	531	XP_016861170.1
	AB046855.1	5	511	BAB13461.1
	AF399708.1	18	2677	AAO38813.1
	AK022714.1	2	220	BAB14198.1
	AK128165.1
	BC144559.1	16	2252

Target Gene Details

• Entrez Gene ID: 64805
• Gene Name: purinergic receptor P2Y12
• Gene Aliases: ADPG-R, BDPLT8, HORK3, P2T(AC), P2Y(12)R, P2Y(AC), P2Y(ADP), P2Y(cyc), P2Y12, SP1999
• Location: Chr.3:151336843-151384812 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
P2RY12	NM_022788.4			NP_073625.1
	AK292096.1
	AK303714.1
	AK316575.1
	BC017898.1			AAH17898.1
	DC313627.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv829757	Chr.3:151327092 - 151508654 on Build GRCh38	Loss	P2RY12 P2RY13 IGSF10 MED12L
nsv954492	Chr.3:151315313 - 151363512 on Build GRCh38	Duplication	P2RY12 GPR87 P2RY13 MED12L
esv3569057	Chr.3:151353276 - 151357565 on Build GRCh38	Loss	P2RY12 MED12L
nsv592045	Chr.3:151052827 - 151377305 on Build GRCh38	Gain	P2RY12 GPR87 P2RY13 GPR171 CLRN1-AS1 MED12L P2RY14

More Information

• Set Membership: Intragenic, Exonic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

general transcription factor, G-protein coupled receptor

Gene Ontology Categories:

Process(es)

transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
adenosine receptor signaling pathway
substrate-dependent cell migration, cell extension
G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
hemostasis
glial cell migration
negative regulation of norepinephrine secretion
G-protein coupled purinergic nucleotide receptor signaling pathway
positive regulation of ion transport
protein kinase B signaling
positive regulation of GTPase activity
negative regulation of cell differentiation
regulation of calcium ion transport
platelet aggregation
calcium ion transmembrane transport
cellular response to ATP
potassium ion transmembrane transport
regulation of microglial cell migration

Function(s)

RNA polymerase II transcription coactivator activity
beta-catenin binding
G-protein coupled adenosine receptor activity
ADP receptor activity
guanyl-nucleotide exchange factor activity