Hs00771298_cn

• Gene Symbol: NPR1
• Assay Reference Genome Location: Chr.1:153679774 on build GRCh38
• Cytoband: 1q21.3

Target Gene Details

• Entrez Gene ID: 4881
• Gene Name: natriuretic peptide receptor 1
• Gene Aliases: ANPRA, ANPa, GUC2A, GUCY2A, NPRA
• Location: Chr.1:153678617-153693992 on Build GRCh38
• Assay Gene Location: Overlaps Exon 1 - Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
NPR1	NM_000906.3			NP_000897.3
	XM_005245218.1			XP_005245275.1
	XM_017001374.1			XP_016856863.1
	AK025024.1
	BC063304.1			AAH63304.1
	X15357.1			CAA33417.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv464028	Chr.1:153649744 - 153750561 on Build GRCh38	Gain	SNAPIN MIR8083 NPR1 ILF2 INTS3
dgv582n54	Chr.1:153639657 - 153750561 on Build GRCh38	Gain	SNAPIN MIR8083 NPR1 CHTOP ILF2 INTS3

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

guanylate cyclase

Gene Ontology Categories:

Process(es)

cGMP biosynthetic process
protein phosphorylation
cell surface receptor signaling pathway
receptor guanylyl cyclase signaling pathway
G-protein coupled receptor signaling pathway
body fluid secretion
regulation of blood pressure
negative regulation of angiogenesis
negative regulation of cell growth
positive regulation of cGMP biosynthetic process
intracellular signal transduction
positive regulation of urine volume
positive regulation of renal sodium excretion
regulation of vasodilation
dopamine metabolic process
regulation of vascular permeability
negative regulation of smooth muscle cell proliferation
regulation of cardiac conduction

Function(s)

adenylate cyclase activity
guanylate cyclase activity
protein kinase activity
ATP binding
GTP binding
G-protein coupled peptide receptor activity
natriuretic peptide receptor activity
peptide hormone binding
protein kinase binding
hormone binding