Hs00780181_cn

• Gene Symbol: TYMS
• Assay Reference Genome Location: Chr.18:657937 on build GRCh38
• Cytoband: 18p11.32

Target Gene Details

• Entrez Gene ID: 7298
• Gene Name: thymidylate synthetase
• Gene Aliases: HST422, TMS, TS
• Location: Chr.18:657604-673499 on Build GRCh38
• Assay Gene Location: Overlaps Exon 1 - Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TYMS	NM_001071.2			NP_001062.1
	AB062290.1			BAB93473.1
	AB077207.1			BAB83676.1
	AB077208.1			BAB83677.1
	AK223372.1			BAD97092.1
	AK292620.1
	AK314140.1
	BC002567.2			AAH02567.1
	BC013919.1			AAH13919.1
	BC083512.1			AAH83512.1
	BT006811.1			AAP35457.1
	X02308.1			CAA26178.1

Target Gene Details

• Entrez Gene ID: 494514
• Gene Name: TYMS opposite strand
• Gene Aliases: C18orf56
• Location: Chr.18:649620-658340 on Build GRCh38
• Assay Gene Location: Within Exon 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TYMSOS	NM_001012716.2	1	404	NP_001012734.2
	AK289986.1	1	333
	BC028301.1	1	404	AAH28301.1
	BM695182.1	1	344

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv576236	Chr.18:319176 - 794272 on Build GRCh38	Gain	ENOSF1 TYMSOS LOC105376854 CLUL1 CETN1 YES1 TYMS COLEC12
esv3641503	Chr.18:640491 - 689131 on Build GRCh38	Gain	ENOSF1 TYMSOS CLUL1 TYMS
nsv576239	Chr.18:394946 - 712037 on Build GRCh38	Gain	ENOSF1 TYMSOS LOC105376854 CLUL1 CETN1 TYMS COLEC12
esv3641497	Chr.18:551569 - 745897 on Build GRCh38	Gain	ENOSF1 TYMSOS CLUL1 CETN1 YES1 TYMS
nsv1060188	Chr.18:575087 - 863351 on Build GRCh38	Gain	ENOSF1 TYMSOS CLUL1 CETN1 YES1 TYMS
esv3893055	Chr.18:415105 - 743226 on Build GRCh38	Gain	ENOSF1 TYMSOS LOC105376854 CLUL1 CETN1 YES1 TYMS COLEC12
nsv482935	Chr.18:10001 - 2900002 on Build GRCh38	Loss	CBX3P2 TYMSOS LOC105376854 MIR8078 THOC1 METTL4 CETN1 ROCK1P1 USP14 ENOSF1 SMCHD1 LINC00470 EMILIN2 LOC101926997 CLUL1 YES1 TYMS LOC388456 NDC80 COLEC12 ADCYAP1
dgv5810n54	Chr.18:351004 - 2238246 on Build GRCh38	Gain	ENOSF1 TYMSOS LINC00470 LOC105376854 CLUL1 CETN1 YES1 TYMS LOC388456 COLEC12 ADCYAP1
nsv576242	Chr.18:567127 - 841320 on Build GRCh38	Gain	ENOSF1 TYMSOS CLUL1 CETN1 YES1 TYMS
nsv528169	Chr.18:551688 - 2240220 on Build GRCh38	Loss	ENOSF1 TYMSOS LINC00470 CLUL1 CETN1 YES1 TYMS LOC388456 ADCYAP1
dgv3307n100	Chr.18:469797 - 683607 on Build GRCh38	Gain	ENOSF1 TYMSOS LOC105376854 CLUL1 CETN1 TYMS COLEC12
nsv833577	Chr.18:521331 - 725019 on Build GRCh38	Gain+Loss	ENOSF1 TYMSOS CLUL1 CETN1 YES1 TYMS
nsv576228	Chr.18:69836 - 1506323 on Build GRCh38	Loss	TYMSOS LOC105376854 MIR8078 THOC1 CETN1 ROCK1P1 USP14 ENOSF1 LINC00470 CLUL1 YES1 TYMS LOC388456 COLEC12 ADCYAP1

More Information

• Set Membership: Intragenic, Exonic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

methyltransferase

Gene Ontology Categories:

Process(es)

G1/S transition of mitotic cell cycle
regulation of transcription involved in G1/S transition of mitotic cell cycle
nucleobase-containing compound metabolic process
dTMP biosynthetic process
dTTP biosynthetic process
aging
circadian rhythm
cell proliferation
deoxyribonucleoside monophosphate biosynthetic process
response to toxic substance
cell growth
immortalization of host cell by virus
uracil metabolic process
organ regeneration
methylation
response to progesterone
response to vitamin A
response to cytokine
tetrahydrofolate interconversion
response to drug
response to ethanol
dUMP metabolic process
pyrimidine nucleoside biosynthetic process
response to organophosphorus
developmental growth
cartilage development
response to glucocorticoid
response to folic acid
intestinal epithelial cell maturation
DNA biosynthetic process

Function(s)

nucleotide binding
mRNA binding
thymidylate synthase activity
folic acid binding
drug binding
protein homodimerization activity
cofactor binding
protein binding