Hs00805217_cn

• Gene Symbol: PDE2A
• Assay Reference Genome Location: Chr.11:72586158 on build GRCh38
• Cytoband: 11q13.4

Target Gene Details

• Entrez Gene ID: 5138
• Gene Name: phosphodiesterase 2A
• Gene Aliases: CGS-PDE, PDE2A1, PED2A4, cGSPDE
• Location: Chr.11:72576140-72674453 on Build GRCh38
• Assay Gene Location: Overlaps Intron 16 - Exon 17

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PDE2A	NM_001143839.3			NP_001137311.1
	NM_001146209.2			NP_001139681.1
	NM_001243784.1			NP_001230713.1
	NM_002599.4			NP_002590.1
	XM_005274040.2			XP_005274097.1
	XM_011545096.2			XP_011543398.1
	XM_017017910.1			XP_016873399.1
	AK092278.1
	AK095024.1
	AK131525.1			BAD18664.1
	AK295676.1
	AK312434.1
	AY495087.1			AAS75513.1
	BC040974.1			AAH40974.1
	U67733.1			AAC51320.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv523601	Chr.11:72570840 - 72719890 on Build GRCh38	Loss	ARAP1 MIR139 LINC01537 PDE2A
nsv1042182	Chr.11:72582998 - 72637447 on Build GRCh38	Gain	MIR139 PDE2A
nsv832207	Chr.11:72561706 - 72758077 on Build GRCh38	Loss	STARD10 ARAP1 MIR139 LINC01537 PDE2A
nsv509429	Chr.11:72573921 - 72604515 on Build GRCh38	Insertion	PDE2A

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

phosphodiesterase

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
cAMP catabolic process
protein targeting to mitochondrion
metabolic process
cAMP-mediated signaling
cGMP-mediated signaling
negative regulation of cAMP biosynthetic process
negative regulation of protein import into nucleus, translocation
cellular response to drug
cellular response to macrophage colony-stimulating factor stimulus
negative regulation of vascular permeability
positive regulation of vascular permeability
cGMP catabolic process
positive regulation of inflammatory response
establishment of endothelial barrier
calcium ion transmembrane transport
cellular response to mechanical stimulus
cellular response to cGMP
cellular response to transforming growth factor beta stimulus

Function(s)

cyclic-nucleotide phosphodiesterase activity
3',5'-cyclic-AMP phosphodiesterase activity
cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
calcium channel activity
protein binding
drug binding
cAMP binding
cGMP binding
TPR domain binding
protein homodimerization activity
metal ion binding
3',5'-cyclic-GMP phosphodiesterase activity