Hs00842545_cn

• Gene Symbol: APC2
• Assay Reference Genome Location: Chr.19:1455432 on build GRCh38
• Cytoband: 19p13.3

Target Gene Details

• Entrez Gene ID: 10297
• Gene Name: APC2, WNT signaling pathway regulator
• Gene Aliases: APCL
• Location: Chr.19:1446268-1473244 on Build GRCh38
• Assay Gene Location: Overlaps Intron 7 - Exon 8

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
APC2	NM_005883.2			NP_005874.1
	XM_005259475.2			XP_005259532.1
	XM_006722607.2			XP_006722670.1
	XM_006722608.3			XP_006722671.2
	XM_006722609.3			XP_006722672.1
	XM_006722610.3			XP_006722673.2
	AB012162.1			BAA34611.1
	AF110334.1			AAD28183.1
	AF128222.1			AAF01784.1
	AJ012652.1			CAB61207.1
	AL078616.1
	BC032573.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv32942	Chr.19:1320268 - 1999205 on Build GRCh38	Gain+Loss	ONECUT3 KLF16 BTBD2 REXO1 ABHD17A ADAT3 SCAMP4 MBD3 MIR1909 RPS15 C19orf25 APC2 DAZAP1 MUM1 UQCR11 NDUFS7 CSNK1G2 ATP8B3 LOC100288123 ADAMTSL5 PLK5 MEX3D GAMT TCF3 CSNK1G2-AS1 REEP6 PCSK4
nsv578279	Chr.19:1413575 - 1530061 on Build GRCh38	Gain	DAZAP1 ADAMTSL5 PLK5 REEP6 RPS15 PCSK4 C19orf25 APC2
nsv833705	Chr.19:1380125 - 1544934 on Build GRCh38	Loss	DAZAP1 ADAMTSL5 PLK5 GAMT NDUFS7 REEP6 RPS15 PCSK4 C19orf25 APC2
esv2758743	Chr.19:951641 - 1544934 on Build GRCh38	Gain+Loss	ATP5D CIRBP SBNO2 ABCA7 WDR18 CBARP RPS15 MIDN RNU6-2 C19orf25 APC2 C19orf24 EFNA2 DAZAP1 LOC105372235 MUM1 GPX4 STK11 NDUFS7 CNN2 GRIN3B CIRBP-AS1 TMEM259 ADAMTSL5 ARHGAP45 ARID3A PLK5 GAMT LOC102725180 REEP6 PCSK4 POLR2E
nsv953942	Chr.19:1371602 - 2057401 on Build GRCh38	Deletion	ONECUT3 KLF16 BTBD2 REXO1 ABHD17A ADAT3 SCAMP4 MBD3 MIR1909 RPS15 C19orf25 APC2 MKNK2 DAZAP1 MUM1 UQCR11 NDUFS7 CSNK1G2 ATP8B3 LOC100288123 ADAMTSL5 PLK5 MEX3D GAMT TCF3 CSNK1G2-AS1 REEP6 PCSK4
nsv470105	Chr.19:1444420 - 1526614 on Build GRCh38	Gain	ADAMTSL5 PLK5 REEP6 PCSK4 C19orf25 APC2

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

cell fate specification
negative regulation of microtubule depolymerization
pattern specification process
cell proliferation
Wnt signaling pathway
cell migration
negative regulation of catenin import into nucleus
regulation of cell differentiation
positive regulation of protein catabolic process
negative regulation of canonical Wnt signaling pathway

Function(s)

protein binding
beta-catenin binding
microtubule binding
gamma-catenin binding