Hs00885539_cn

• Gene Symbol: MUL1
• Assay Reference Genome Location: Chr.1:20501222 on build GRCh38
• Cytoband: 1p36.12

Target Gene Details

• Entrez Gene ID: 79594
• Gene Name: mitochondrial E3 ubiquitin protein ligase 1
• Gene Aliases: C1orf166, GIDE, MAPL, MULAN, RNF218
• Location: Chr.1:20499448-20508483 on Build GRCh38
• Assay Gene Location: Within Exon 4

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
MUL1	NM_024544.2	4	684	NP_078820.2
	XM_011542137.2	4	1367	XP_011540439.1
	AB097015.1	4	629	BAC77368.1
	AK022937.1	4	670	BAB14317.1
	AK293430.1
	AK303820.1	4	940
	AL833889.1	4	631	CAD38745.1
	BC010101.2	4	591	AAH10101.1
	BC014010.1	4	584	AAH14010.1
	EU935008.1	4	527

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv545731	Chr.1:19989106 - 20776306 on Build GRCh38	Gain	LINC01141 PLA2G5 DDOST FAM43B MUL1 PLA2G2C UBXN10 PLA2G2F CDA VWA5B1 PINK1-AS KIF17 MIR6084 SH2D5 CAMK2N1 UBXN10-AS1 PLA2G2D PINK1 HP1BP3

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Gene Ontology Categories:

Process(es)

mitochondrial fission
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
activation of JUN kinase activity
negative regulation of mitochondrial fusion
regulation of mitochondrion organization
protein ubiquitination
protein sumoylation
negative regulation of cell growth
protein destabilization
positive regulation of protein sumoylation
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of innate immune response
negative regulation of defense response to virus by host
protein stabilization
mitochondrion localization
regulation of mitochondrial membrane potential
negative regulation of protein kinase B signaling
negative regulation of type I interferon-mediated signaling pathway
cellular response to exogenous dsRNA
negative regulation of chemokine (C-C motif) ligand 5 production
positive regulation of mitochondrial fission
regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
positive regulation of dendrite extension

Function(s)

ubiquitin-protein transferase activity
signal transducer activity
protein binding
zinc ion binding
ligase activity
SUMO transferase activity
ubiquitin protein ligase binding
identical protein binding