Hs00962405_cn

• Gene Symbol: PARP10
• Assay Reference Genome Location: Chr.8:143983306 on build GRCh38
• Cytoband: 8q24.3

Target Gene Details

• Entrez Gene ID: 84875
• Gene Name: poly(ADP-ribose) polymerase family member 10
• Gene Aliases: ARTD10
• Location: Chr.8:143977152-143986471 on Build GRCh38
• Assay Gene Location: Within Exon 7

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PARP10	NM_001317895.1	7	2519	NP_001304824.1
	NM_032789.4	8	2395	NP_116178.2
	NR_134234.1
	XM_011517336.2	8	2335	XP_011515638.1
	AK027370.1	8	2352	BAB55067.1
	AK075250.1	4	1082	BAC11498.1
	AK124017.1	1	1053
	AK128537.1	9	2210
	AK129821.1	4	873
	AK222914.1	8	2378	BAD96634.1
	AK303317.1	7	2444
	BC014229.2	1	379	AAH14229.2
	BC019030.2	4	1215	AAH19030.2
	BC132961.1	8	2346
	BC136542.1	8	2346

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv6445	Chr.8:143961415 - 143994522 on Build GRCh38	Insertion	PLEC GRINA PARP10
nsv470249	Chr.8:143889098 - 144519234 on Build GRCh38	Loss	MIR6849 LOC101928902 CYHR1 MIR7112 MAF1 TMEM249 HSF1 MFSD3 PARP10 MROH1 MIR661 MIR6847 MIR1234 OPLAH RECQL4 CYC1 FBXL6 DGAT1 GPT SLC39A4 VPS28 MIR6848 MIR939 BOP1 HGH1 PLEC EXOSC4 CPSF1 SHARPIN SPATC1 LOC101928953 SCX SCRT1 SLC52A2 PPP1R16A SMPD5 KIFC2 LRRC14 TONSL WDR97 FOXH1 GPAA1 MIR6893 ADCK5 GRINA MIR6846 TONSL-AS1
nsv515809	Chr.8:143904439 - 144519234 on Build GRCh38	Gain+Loss	MIR6849 LOC101928902 CYHR1 MIR7112 MAF1 TMEM249 HSF1 MFSD3 PARP10 MROH1 MIR661 MIR6847 MIR1234 OPLAH RECQL4 CYC1 FBXL6 DGAT1 GPT SLC39A4 VPS28 MIR6848 MIR939 BOP1 HGH1 PLEC EXOSC4 CPSF1 SHARPIN SPATC1 LOC101928953 SCX SCRT1 SLC52A2 PPP1R16A SMPD5 KIFC2 LRRC14 TONSL WDR97 FOXH1 GPAA1 MIR6893 ADCK5 GRINA MIR6846 TONSL-AS1
nsv612914	Chr.8:143972494 - 144120626 on Build GRCh38	Loss	PLEC EXOSC4 MAF1 SHARPIN SPATC1 PARP10 MIR6847 OPLAH SMPD5 CYC1 WDR97 GPAA1 GRINA MIR6846
dgv12431n54	Chr.8:143845100 - 144161320 on Build GRCh38	Loss	HGH1 PLEC EXOSC4 MAF1 SHARPIN SPATC1 PARP10 EPPK1 MROH1 MIR661 MIR6847 OPLAH SMPD5 CYC1 WDR97 GPAA1 GRINA MIR6846
nsv950015	Chr.8:143866633 - 144125597 on Build GRCh38	Deletion	PLEC EXOSC4 MAF1 SHARPIN SPATC1 PARP10 EPPK1 MIR661 MIR6847 OPLAH SMPD5 CYC1 WDR97 GPAA1 GRINA MIR6846
nsv1161815	Chr.8:143775169 - 144080674 on Build GRCh38	Deletion	PLEC EXOSC4 SPATC1 PARP10 EPPK1 MIR6845 MIR661 MIR937 MIR6847 OPLAH SMPD5 SCRIB NRBP2 LOC642574 PUF60 GRINA MIR6846
nsv470250	Chr.8:143917934 - 144097007 on Build GRCh38	Gain	MIR6847 OPLAH SMPD5 PLEC CYC1 EXOSC4 GPAA1 SPATC1 GRINA MIR6846 PARP10 MIR661
dgv12433n54	Chr.8:143902404 - 144120626 on Build GRCh38	Gain	PLEC EXOSC4 MAF1 SHARPIN SPATC1 PARP10 MIR661 MIR6847 OPLAH SMPD5 CYC1 WDR97 GPAA1 GRINA MIR6846
nsv612906	Chr.8:143917935 - 144090784 on Build GRCh38	Loss	MIR6847 OPLAH SMPD5 PLEC EXOSC4 GPAA1 SPATC1 GRINA MIR6846 PARP10 MIR661

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Gene Ontology Categories:

Process(es)

protein ADP-ribosylation
negative regulation of gene expression
regulation of chromatin assembly
negative regulation of NF-kappaB transcription factor activity
negative regulation of protein import into nucleus, translocation
negative regulation of viral genome replication
negative regulation of fibroblast proliferation
protein poly-ADP-ribosylation
protein auto-ADP-ribosylation
negative regulation of protein K63-linked ubiquitination

Function(s)

NAD+ ADP-ribosyltransferase activity
protein binding
K63-linked polyubiquitin binding