Hs01112000_cn

• Gene Symbol: FAM227B
• Assay Reference Genome Location: Chr.15:49424401 on build GRCh38
• Cytoband: 15q21.2

Target Gene Details

• Entrez Gene ID: 196951
• Gene Name: family with sequence similarity 227 member B
• Gene Aliases: C15orf33
• Location: Chr.15:49326997-49620931 on Build GRCh38
• Assay Gene Location: Within Intron 16

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
FAM227B	NM_152647.2			NP_689860.2
	XM_005254213.3			XP_005254270.1
	XM_005254214.3			XP_005254271.1
	XM_005254215.3			XP_005254272.1
	XM_005254216.3			XP_005254273.1
	XM_005254219.3			XP_005254276.1
	XM_006720423.2			XP_006720486.1
	XM_006720424.2			XP_006720487.1
	XM_006720426.2			XP_006720489.1
	XM_006720427.3			XP_006720490.1
	XM_011521319.2			XP_011519621.1
	XM_011521320.1			XP_011519622.1
	XM_011521321.2			XP_011519623.1
	XM_011521322.1			XP_011519624.1
	XM_011521324.1			XP_011519626.1
	XM_011521326.1			XP_011519628.1
	XM_017021990.1			XP_016877479.1
	XM_017021991.1			XP_016877480.1
	XM_017021992.1			XP_016877481.1
	XM_017021993.1			XP_016877482.1
	XM_017021994.1			XP_016877483.1
	XM_017021995.1			XP_016877484.1
	XM_017021996.1			XP_016877485.1
	AK057362.1			BAB71451.1
	BC048125.1			AAH48125.1

Target Gene Details

• Entrez Gene ID: 2252
• Gene Name: fibroblast growth factor 7
• Gene Aliases: HBGF-7, KGF
• Location: Chr.15:49423178-49487326 on Build GRCh38
• Assay Gene Location: Within Exon 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
FGF7	NM_002009.3	2	633	NP_002000.1
	AK313160.1	2	551
	BC010956.1	2	574	AAH10956.1
	CR542002.1	1	104	CAG46799.1
	M60828.1	2	549	AAA63210.1
	S81661.1	2	549	AAB21431.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv833002	Chr.15:49329203 - 49489602 on Build GRCh38	Gain	GALK2 FAM227B FGF7

More Information

• Set Membership: Intragenic, Exonic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

growth factor, intercellular signal molecule

Gene Ontology Categories:

Process(es)

MAPK cascade
ovarian follicle development
positive regulation of defense response to virus by host
phosphatidylcholine biosynthetic process
signal transduction
positive regulation of cell proliferation
fibroblast growth factor receptor signaling pathway
epidermis development
response to wounding
mesenchymal cell proliferation
positive regulation of keratinocyte proliferation
regulation of phosphatidylinositol 3-kinase signaling
peptidyl-tyrosine phosphorylation
hair follicle morphogenesis
actin cytoskeleton reorganization
protein localization to cell surface
phosphatidylinositol-3-phosphate biosynthetic process
wound healing
surfactant homeostasis
positive regulation of GTPase activity
positive regulation of transcription, DNA-templated
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
positive regulation of epithelial cell proliferation
positive regulation of peptidyl-tyrosine phosphorylation
positive chemotaxis
positive regulation of keratinocyte migration
positive regulation of cell division
branching involved in salivary gland morphogenesis
positive regulation of epithelial cell proliferation involved in lung morphogenesis
regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
secretion by lung epithelial cell involved in lung growth
xenophagy

Function(s)

protein tyrosine kinase activity
Ras guanyl-nucleotide exchange factor activity
type 2 fibroblast growth factor receptor binding
protein binding
growth factor activity
heparin binding
1-phosphatidylinositol-3-kinase activity
chemoattractant activity
phosphatidylinositol-4,5-bisphosphate 3-kinase activity