Hs01326481_cn

• Gene Symbol: MCL1
• Assay Reference Genome Location: Chr.1:150579597 on build GRCh38
• Cytoband: 1q21.2

Target Gene Details

• Entrez Gene ID: 4170
• Gene Name: BCL2 family apoptosis regulator
• Gene Aliases: BCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EAT
• Location: Chr.1:150574551-150579738 on Build GRCh38
• Assay Gene Location: Within Exon 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
MCL1	NM_001197320.1	1	142	NP_001184249.1
	NM_021960.4	1	142	NP_068779.1
	NM_182763.2	1	142	NP_877495.1
	AA453505.1	1	305
	AF118124.1			AAD13299.1
	AK294462.1
	AK297217.1
	AK300499.1
	AK304775.1
	AK312508.1
	AK316267.1
	BC017197.2			AAH17197.1
	BC071897.1			AAH71897.1
	BC107735.1			AAI07736.1
	L08246.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1006838	Chr.1:150453465 - 150750307 on Build GRCh38	Gain	MCL1 GOLPH3L LOC100289061 RPRD2 CTSS MIR4257 ENSA ADAMTSL4 FALEC ADAMTSL4-AS1 HORMAD1 MIR6878 LOC107983947 ECM1 TARS2

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Gene Ontology Categories:

Process(es)

cell fate determination
multicellular organism development
intrinsic apoptotic signaling pathway in response to DNA damage
apoptotic mitochondrial changes
cellular homeostasis
response to cytokine
negative regulation of apoptotic process
protein transmembrane transport
extrinsic apoptotic signaling pathway in absence of ligand
positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
negative regulation of anoikis
regulation of response to DNA damage stimulus
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
negative regulation of intrinsic apoptotic signaling pathway

Function(s)

protein binding
protein channel activity
protein homodimerization activity
protein heterodimerization activity
BH3 domain binding