Hs01330023_cn

• Gene Symbol: POLR3C
• Assay Reference Genome Location: Chr.1:145840117 on build GRCh38
• Cytoband: 1q21.1

Target Gene Details

• Entrez Gene ID: 10623
• Gene Name: RNA polymerase III subunit C
• Gene Aliases: RPC3, RPC62
• Location: Chr.1:145823183-145844402 on Build GRCh38
• Assay Gene Location: Overlaps Intron 14 - Exon 15

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
POLR3C	NM_001303456.1			NP_001290385.1
	NM_006468.7			NP_006459.3
	XM_005272927.3			XP_005272984.1
	XM_005272928.3			XP_005272985.1
	AK223413.1			BAD97133.1
	AY091463.1			AAM12033.1
	BC002586.1			AAH02586.1
	BC004424.1			AAH04424.1
	DA291657.1
	U93867.1			AAB63675.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1005055	Chr.1:145642988 - 148991068 on Build GRCh38	Loss	ITGA10 POLR3C GPR89A LOC105371242 NBPF13P LIX1L NOTCH2NL LOC100132057 NBPF12 CD160 NUDT4P1 ANKRD34A CHD1L POLR3GL NBPF14 GJA5 RNF115 LOC105371226 PEX11B ACP6 TXNIP CH17-408M7.1 NBPF10 NUDT4P2 MIR6736 PDE4DIP LOC101927468 LOC284561 LOC101928979 MIR5087 GNRHR2 LINC00624 RBM8A RNVU1-7 RNVU1-1 PPIAL4G RNVU1-6 PIAS3 RNVU1-8 MIR6077 LOC100505824 NUDT17 BCL9 ANKRD35 LOC100996517 GPR89B RNVU1-3 LINC01138 PDZK1 GJA8 HYDIN2 NBPF11 RNU1-13P PRKAB2 LOC728989 PDIA3P1 PDZK1P1 LOC100996763 FMO5 HFE2
esv3587420	Chr.1:145824369 - 145905171 on Build GRCh38	Gain	MIR6736 ITGA10 NUDT17 POLR3C PIAS3 ANKRD35
nsv831381	Chr.1:145784568 - 145960930 on Build GRCh38	Gain	RBM8A ITGA10 POLR3C PIAS3 PEX11B LIX1L MIR6736 NUDT17 ANKRD34A POLR3GL ANKRD35 GNRHR2 RNF115
esv3572008	Chr.1:145837994 - 145846568 on Build GRCh38	Gain	NUDT17 POLR3C

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

DNA-directed RNA polymerase, RNA metabolism protein, nucleic acid metabolism protein

Gene Ontology Categories:

Process(es)

regulation of transcription from RNA polymerase III promoter
transcription from RNA polymerase III promoter
positive regulation of type I interferon production
positive regulation of interferon-beta production
innate immune response
positive regulation of innate immune response
defense response to virus

Function(s)

RNA polymerase III activity
DNA binding
DNA-directed RNA polymerase activity
protein binding