Hs01390037_cn

• Gene Symbol: MGAT4B
• Assay Reference Genome Location: Chr.5:179806820 on build GRCh38
• Cytoband: 5q35.3

Target Gene Details

• Entrez Gene ID: 11282
• Gene Name: mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
• Gene Aliases: GNT-IV, GNT-IVB
• Location: Chr.5:179797597-179806952 on Build GRCh38
• Assay Gene Location: Within Exon 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
MGAT4B	NM_014275.4	1	133	NP_055090.1
	XM_017008998.1			XP_016864487.1
	AL537522.3	1	133
	BC051835.1			AAH51835.1
	CN369872.1	1	122

Target Gene Details

• Entrez Gene ID: 8878
• Gene Name: sequestosome 1
• Gene Aliases: A170, FTDALS3, OSIL, PDB3, ZIP3, p60, p62, p62B
• Location: Chr.5:179806388-179838078 on Build GRCh38
• Assay Gene Location: Within Exon 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
SQSTM1	NM_001142298.1			NP_001135770.1
	XM_011534683.2	1	211	XP_011532985.1
	BC001874.1			AAH01874.1
	BI549805.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1133621	Chr.5:179805800 - 179807200 on Build GRCh38	Deletion	SQSTM1 MGAT4B
nsv469579	Chr.5:179757830 - 179933191 on Build GRCh38	Loss	MIR1229 SQSTM1 RNF130 C5orf45 MAML1 LOC100996419 LTC4S MGAT4B TBC1D9B
nsv600668	Chr.5:179800865 - 179815581 on Build GRCh38	Loss	SQSTM1 MGAT4B
esv988291	Chr.5:179806076 - 179813737 on Build GRCh38	Deletion	SQSTM1 MGAT4B
esv3570596	Chr.5:179804973 - 179813403 on Build GRCh38	Loss	SQSTM1 MGAT4B
nsv823361	Chr.5:179786323 - 179824243 on Build GRCh38	Loss	MIR1229 SQSTM1 LTC4S MGAT4B

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

transferase

Gene Ontology Categories:

Process(es)

N-glycan processing
mitophagy
positive regulation of protein phosphorylation
immune system process
protein phosphorylation
ubiquitin-dependent protein catabolic process
autophagy
apoptotic process
response to stress
protein localization
regulation of mitochondrion organization
endosomal transport
macroautophagy
positive regulation of macroautophagy
cell differentiation
intracellular signal transduction
positive regulation of apoptotic process
negative regulation of apoptotic process
regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of growth of symbiont in host
positive regulation of transcription from RNA polymerase II promoter
regulation of Ras protein signal transduction
protein heterooligomerization
regulation of protein complex stability
mitophagy in response to mitochondrial depolarization

Function(s)

alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity
metal ion binding
protein serine/threonine kinase activity
protein kinase C binding
protein binding
zinc ion binding
protein kinase binding
receptor tyrosine kinase binding
ubiquitin protein ligase binding
SH2 domain binding
identical protein binding
protein homodimerization activity
ubiquitin binding
K63-linked polyubiquitin binding