Hs01434775_cn

• Gene Symbol: PARP10
• Assay Reference Genome Location: Chr.8:143977732 on build GRCh38
• Cytoband: 8q24.3

Target Gene Details

• Entrez Gene ID: 84875
• Gene Name: poly(ADP-ribose) polymerase family member 10
• Gene Aliases: ARTD10
• Location: Chr.8:143977152-143986471 on Build GRCh38
• Assay Gene Location: Within Exon 10

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PARP10	NM_001317895.1	10	3066	NP_001304824.1
	NM_032789.4	11	2942	NP_116178.2
	NR_134234.1	11	2797
	XM_011517336.2	11	2882	XP_011515638.1
	AK027370.1	11	2899	BAB55067.1
	AK075250.1	7	1629	BAC11498.1
	AK124017.1	4	1600
	AK128537.1	12	2757
	AK129821.1	7	1420
	AK222914.1	11	2925	BAD96634.1
	AK303317.1	10	2991
	BC014229.2	4	926	AAH14229.2
	BC019030.2	7	1762	AAH19030.2
	BC132961.1	11	2893
	BC136542.1	11	2893

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv6445	Chr.8:143961415 - 143994522 on Build GRCh38	Insertion	PLEC GRINA PARP10
nsv470249	Chr.8:143889098 - 144519234 on Build GRCh38	Loss	PPP1R16A HSF1 CYHR1 WDR97 TONSL MIR939 HGH1 TONSL-AS1 DGAT1 BOP1 RECQL4 SHARPIN CPSF1 GRINA MIR6849 MIR6893 PARP10 EXOSC4 KIFC2 FBXL6 SLC52A2 LRRC14 MIR1234 SLC39A4 FOXH1 CYC1 GPAA1 MIR6848 SMPD5 SCX GPT MIR661 SCRT1 OPLAH MROH1 ADCK5 PLEC MFSD3 TMEM249 MIR6847 LOC101928902 MIR6846 LOC101928953 MIR7112 SPATC1 MAF1 VPS28
nsv515809	Chr.8:143904439 - 144519234 on Build GRCh38	Gain+Loss	PPP1R16A HSF1 CYHR1 WDR97 TONSL MIR939 HGH1 TONSL-AS1 DGAT1 BOP1 RECQL4 SHARPIN CPSF1 GRINA MIR6849 MIR6893 PARP10 EXOSC4 KIFC2 FBXL6 SLC52A2 LRRC14 MIR1234 SLC39A4 FOXH1 CYC1 GPAA1 MIR6848 SMPD5 SCX GPT MIR661 SCRT1 OPLAH MROH1 ADCK5 PLEC MFSD3 TMEM249 MIR6847 LOC101928902 MIR6846 LOC101928953 MIR7112 SPATC1 MAF1 VPS28
nsv612914	Chr.8:143972494 - 144120626 on Build GRCh38	Loss	CYC1 GPAA1 SMPD5 WDR97 OPLAH SHARPIN PLEC GRINA MIR6847 PARP10 EXOSC4 MIR6846 SPATC1 MAF1
dgv12431n54	Chr.8:143845100 - 144161320 on Build GRCh38	Loss	CYC1 GPAA1 SMPD5 WDR97 HGH1 MIR661 EPPK1 OPLAH MROH1 SHARPIN PLEC GRINA MIR6847 PARP10 EXOSC4 MIR6846 SPATC1 MAF1
nsv950015	Chr.8:143866633 - 144125597 on Build GRCh38	Deletion	CYC1 GPAA1 SMPD5 WDR97 MIR661 EPPK1 OPLAH SHARPIN PLEC GRINA MIR6847 PARP10 EXOSC4 MIR6846 SPATC1 MAF1
nsv1161815	Chr.8:143775169 - 144080674 on Build GRCh38	Deletion	MIR6845 SCRIB MIR937 SMPD5 MIR661 EPPK1 OPLAH PLEC GRINA MIR6847 PARP10 NRBP2 EXOSC4 MIR6846 LOC642574 SPATC1 PUF60
nsv470250	Chr.8:143917934 - 144097007 on Build GRCh38	Gain	OPLAH PLEC GRINA CYC1 GPAA1 MIR6847 PARP10 EXOSC4 MIR6846 SMPD5 SPATC1 MIR661
dgv12433n54	Chr.8:143902404 - 144120626 on Build GRCh38	Gain	CYC1 GPAA1 SMPD5 WDR97 MIR661 OPLAH SHARPIN PLEC GRINA MIR6847 PARP10 EXOSC4 MIR6846 SPATC1 MAF1
nsv612906	Chr.8:143917935 - 144090784 on Build GRCh38	Loss	OPLAH PLEC GRINA GPAA1 MIR6847 PARP10 EXOSC4 MIR6846 SMPD5 SPATC1 MIR661

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Gene Ontology Categories:

Process(es)

protein ADP-ribosylation
negative regulation of gene expression
regulation of chromatin assembly
negative regulation of NF-kappaB transcription factor activity
negative regulation of protein import into nucleus, translocation
negative regulation of viral genome replication
negative regulation of fibroblast proliferation
protein poly-ADP-ribosylation
protein auto-ADP-ribosylation
negative regulation of protein K63-linked ubiquitination

Function(s)

NAD+ ADP-ribosyltransferase activity
protein binding
K63-linked polyubiquitin binding