Hs01484593_cn

• Gene Symbol: PARP10
• Assay Reference Genome Location: Chr.8:143983471 on build GRCh38
• Cytoband: 8q24.3

Target Gene Details

• Entrez Gene ID: 84875
• Gene Name: poly(ADP-ribose) polymerase family member 10
• Gene Aliases: ARTD10
• Location: Chr.8:143977152-143986471 on Build GRCh38
• Assay Gene Location: Within Exon 7

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PARP10	NM_001317895.1	7	2354	NP_001304824.1
	NM_032789.4	8	2230	NP_116178.2
	NR_134234.1	8	2230
	XM_011517336.2	8	2170	XP_011515638.1
	AK027370.1	8	2187	BAB55067.1
	AK075250.1	4	917	BAC11498.1
	AK124017.1	1	888
	AK128537.1	9	2045
	AK129821.1	4	708
	AK222914.1	8	2213	BAD96634.1
	AK303317.1	7	2279
	BC014229.2	1	214	AAH14229.2
	BC019030.2	4	1050	AAH19030.2
	BC132961.1	8	2181
	BC136542.1	8	2181

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv6445	Chr.8:143961415 - 143994522 on Build GRCh38	Insertion	PARP10 PLEC GRINA
nsv470249	Chr.8:143889098 - 144519234 on Build GRCh38	Loss	LOC101928902 MIR939 KIFC2 PPP1R16A LRRC14 FBXL6 MIR6847 MFSD3 ADCK5 MIR7112 SCX TMEM249 SHARPIN MIR1234 WDR97 CYC1 SMPD5 SPATC1 SLC52A2 MIR6846 DGAT1 MIR661 HSF1 TONSL-AS1 SLC39A4 MAF1 MIR6893 CYHR1 LOC101928953 FOXH1 PARP10 GPAA1 CPSF1 SCRT1 VPS28 RECQL4 BOP1 MIR6848 EXOSC4 OPLAH HGH1 GPT MROH1 TONSL MIR6849 PLEC GRINA
nsv515809	Chr.8:143904439 - 144519234 on Build GRCh38	Gain+Loss	LOC101928902 MIR939 KIFC2 PPP1R16A LRRC14 FBXL6 MIR6847 MFSD3 ADCK5 MIR7112 SCX TMEM249 SHARPIN MIR1234 WDR97 CYC1 SMPD5 SPATC1 SLC52A2 MIR6846 DGAT1 MIR661 HSF1 TONSL-AS1 SLC39A4 MAF1 MIR6893 CYHR1 LOC101928953 FOXH1 PARP10 GPAA1 CPSF1 SCRT1 VPS28 RECQL4 BOP1 MIR6848 EXOSC4 OPLAH HGH1 GPT MROH1 TONSL MIR6849 PLEC GRINA
nsv612914	Chr.8:143972494 - 144120626 on Build GRCh38	Loss	PARP10 GPAA1 MIR6847 SHARPIN EXOSC4 WDR97 OPLAH CYC1 SMPD5 SPATC1 MIR6846 MAF1 PLEC GRINA
dgv12431n54	Chr.8:143845100 - 144161320 on Build GRCh38	Loss	PARP10 GPAA1 EPPK1 MIR6847 SHARPIN EXOSC4 WDR97 OPLAH CYC1 SMPD5 SPATC1 HGH1 MIR6846 MROH1 MIR661 MAF1 PLEC GRINA
nsv950015	Chr.8:143866633 - 144125597 on Build GRCh38	Deletion	PARP10 GPAA1 EPPK1 MIR6847 SHARPIN EXOSC4 WDR97 OPLAH CYC1 SMPD5 SPATC1 MIR6846 MIR661 MAF1 PLEC GRINA
nsv1161815	Chr.8:143775169 - 144080674 on Build GRCh38	Deletion	MIR6845 PARP10 EPPK1 MIR6847 SCRIB LOC642574 NRBP2 MIR937 EXOSC4 OPLAH SMPD5 SPATC1 MIR6846 MIR661 PLEC PUF60 GRINA
nsv470250	Chr.8:143917934 - 144097007 on Build GRCh38	Gain	PARP10 GPAA1 EXOSC4 OPLAH CYC1 SMPD5 SPATC1 MIR6847 MIR6846 MIR661 PLEC GRINA
dgv12433n54	Chr.8:143902404 - 144120626 on Build GRCh38	Gain	PARP10 GPAA1 MIR6847 SHARPIN EXOSC4 WDR97 OPLAH CYC1 SMPD5 SPATC1 MIR6846 MIR661 MAF1 PLEC GRINA
nsv612906	Chr.8:143917935 - 144090784 on Build GRCh38	Loss	PARP10 GPAA1 EXOSC4 OPLAH SMPD5 SPATC1 MIR6847 MIR6846 MIR661 PLEC GRINA

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Gene Ontology Categories:

Process(es)

protein ADP-ribosylation
negative regulation of gene expression
regulation of chromatin assembly
negative regulation of NF-kappaB transcription factor activity
negative regulation of protein import into nucleus, translocation
negative regulation of viral genome replication
negative regulation of fibroblast proliferation
protein poly-ADP-ribosylation
protein auto-ADP-ribosylation
negative regulation of protein K63-linked ubiquitination

Function(s)

NAD+ ADP-ribosyltransferase activity
protein binding
K63-linked polyubiquitin binding