Hs01770230_cn

• Gene Symbol: KCNS2
• Assay Reference Genome Location: Chr.8:98430198 on build GRCh38
• Cytoband: 8q22.2

Target Gene Details

• Entrez Gene ID: 3788
• Gene Name: potassium voltage-gated channel modifier subfamily S member 2
• Gene Aliases: KV9.2
• Location: Chr.8:98427022-98430797 on Build GRCh38
• Assay Gene Location: Within Exon 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
KCNS2	NM_020697.3	2	2569	NP_065748.1
	AB032970.1	2	2374
	BC034778.1	2	2569	AAH34778.1

Target Gene Details

• Entrez Gene ID: 6788
• Gene Name: serine/threonine kinase 3
• Gene Aliases: KRS1, MST2
• Location: Chr.8:98429677-98944329 on Build GRCh38
• Assay Gene Location: Within Exon 27

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
STK3	XM_011517251.1	12	4953	XP_011515553.1
	XM_011517253.2	10	4622	XP_011515555.1
	XM_011517255.2	8	5075	XP_011515557.1
	XM_011517258.1	7	4187	XP_011515560.1
	XM_017013759.1	14	5288	XP_016869248.1
	XM_017013760.1	13	5151	XP_016869249.1
	XM_017013763.1	8	4267	XP_016869252.1
	XM_017013764.1	7	5012	XP_016869253.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1034492	Chr.8:98424113 - 98444288 on Build GRCh38	Gain	KCNS2 STK3
nsv831406	Chr.8:98278517 - 98469848 on Build GRCh38	Loss	KCNS2 NIPAL2 STK3

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

voltage-gated ion channel, non-receptor serine/threonine protein kinase

Gene Ontology Categories:

Process(es)

potassium ion transport
protein homooligomerization
potassium ion transmembrane transport
regulation of delayed rectifier potassium channel activity
neural tube formation
endocardium development
protein phosphorylation
apoptotic process
signal transduction
central nervous system development
negative regulation of cell proliferation
signal transduction by protein phosphorylation
positive regulation of protein binding
hippo signaling
intracellular signal transduction
positive regulation of apoptotic process
positive regulation of fat cell differentiation
positive regulation of JNK cascade
negative regulation of organ growth
protein stabilization
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of protein kinase B signaling
primitive hemopoiesis
cell differentiation involved in embryonic placenta development
regulation of cell differentiation involved in embryonic placenta development
positive regulation of protein serine/threonine kinase activity
negative regulation of canonical Wnt signaling pathway
hepatocyte apoptotic process
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors

Function(s)

delayed rectifier potassium channel activity
protein binding
magnesium ion binding
protein kinase activity
protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
ATP binding
protein serine/threonine kinase activator activity
protein dimerization activity