Hs02103489_cn

• Gene Symbol: MED12L
• Assay Reference Genome Location: Chr.3:151368199 on build GRCh38
• Cytoband: 3q25.1

Target Gene Details

• Entrez Gene ID: 116931
• Gene Name: mediator complex subunit 12 like
• Gene Aliases: NOPAR, TNRC11L, TRALP, TRALPUSH
• Location: Chr.3:151085665-151436677 on Build GRCh38
• Assay Gene Location: Overlaps Exon 26 - Intron 26

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
MED12L	NM_053002.5			NP_443728.3
	XM_006713487.3			XP_006713550.1
	XM_011512390.2			XP_011510692.1
	XM_011512394.2			XP_011510696.1
	XM_011512399.2			XP_011510701.1
	XM_017005676.1			XP_016861165.1
	XM_017005677.1			XP_016861166.1
	XM_017005678.1			XP_016861167.1
	XM_017005679.1			XP_016861168.1
	XM_017005680.1			XP_016861169.1
	XM_017005681.1			XP_016861170.1
	AB046855.1			BAB13461.1
	AF399708.1			AAO38813.1
	AK022714.1			BAB14198.1
	AK128165.1
	BC144559.1

Target Gene Details

• Entrez Gene ID: 64805
• Gene Name: purinergic receptor P2Y12
• Gene Aliases: ADPG-R, BDPLT8, HORK3, P2T(AC), P2Y(12)R, P2Y(AC), P2Y(ADP), P2Y(cyc), P2Y12, SP1999
• Location: Chr.3:151336843-151384812 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
P2RY12	NM_022788.4			NP_073625.1
	AK292096.1
	AK303714.1
	AK316575.1
	BC017898.1			AAH17898.1
	DC313627.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv829757	Chr.3:151327092 - 151508654 on Build GRCh38	Loss	MED12L IGSF10 P2RY13 P2RY12
nsv592045	Chr.3:151052827 - 151377305 on Build GRCh38	Gain	GPR87 CLRN1-AS1 MED12L GPR171 P2RY13 P2RY14 P2RY12

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

general transcription factor, G-protein coupled receptor

Gene Ontology Categories:

Process(es)

transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
adenosine receptor signaling pathway
substrate-dependent cell migration, cell extension
G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
hemostasis
glial cell migration
negative regulation of norepinephrine secretion
G-protein coupled purinergic nucleotide receptor signaling pathway
positive regulation of ion transport
protein kinase B signaling
positive regulation of GTPase activity
negative regulation of cell differentiation
regulation of calcium ion transport
platelet aggregation
calcium ion transmembrane transport
cellular response to ATP
potassium ion transmembrane transport
regulation of microglial cell migration

Function(s)

RNA polymerase II transcription coactivator activity
beta-catenin binding
G-protein coupled adenosine receptor activity
ADP receptor activity
guanyl-nucleotide exchange factor activity