Hs02123418_cn

• Gene Symbol: FBXW5
• Assay Reference Genome Location: Chr.9:136942379 on build GRCh38
• Cytoband: 9q34.3

Target Gene Details

• Entrez Gene ID: 54461
• Gene Name: F-box and WD repeat domain containing 5
• Gene Aliases: Fbw5
• Location: Chr.9:136940433-136944774 on Build GRCh38
• Assay Gene Location: Within Exon 6

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
FBXW5	NM_018998.3	6	947	NP_061871.1
	XM_005266089.2	6	997	XP_005266146.2
	XM_011518789.1	6	997	XP_011517091.1
	XM_017014812.1	6	967	XP_016870301.1
	AB209726.1	3	359	BAD92963.1
	AF217998.1	2	109	AAG17240.1
	AF258569.1	2	109	AAG23772.1
	AK026081.1	6	811	BAB15354.1
	AK315738.1	6	822
	AL137631.1	2	210	CAB70851.1
	BC004541.2	3	356	AAH04541.2
	BC009429.1	1	100	AAH09429.1
	BC014130.1	6	843	AAH14130.1
	BC014297.2	6	814	AAH14297.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv951205	Chr.9:136821949 - 136944648 on Build GRCh38	Deletion	MAMDC4 FBXW5 EDF1 TRAF2 MIR4292 C9orf172 PHPT1 MIR4479 RABL6
esv997310	Chr.9:136936844 - 136943246 on Build GRCh38	Deletion	FBXW5
nsv818738	Chr.9:136740043 - 137009585 on Build GRCh38	Gain	LCN15 LOC100128593 FBXW5 EDF1 PHPT1 C9orf142 RABL6 CCDC183-AS1 CLIC3 LCNL1 LCN6 MAMDC4 MIR6722 TRAF2 C9orf172 MIR4479 PTGDS C8G ABCA2 MIR4292 CCDC183 PRR31 LCN12 LCN10 LCN8 TMEM141
nsv524322	Chr.9:136795692 - 137482216 on Build GRCh38	Loss	FBXW5 PHPT1 TOR4A CCDC183-AS1 CLIC3 MAMDC4 MIR3621 RNF208 NPDC1 TRAF2 STPG3 CYSRT1 FAM166A C9orf172 PTGDS C8G ABCA2 MIR7114 NOXA1 MIR4292 CCDC183 PRR31 NELFB EXD3 TPRN MAN1B1-AS1 NRARP SAPCD2 ENTPD2 EDF1 UAP1L1 C9orf142 ENTPD8 RABL6 NDOR1 LCNL1 SSNA1 C9orf139 TUBB4B RNF224 TMEM210 DPP7 C9orf173-AS1 MIR4479 MAN1B1 SLC34A3 LOC101930307 PNPLA7 ANAPC2 GRIN1 FUT7 LCN12 NSMF TMEM203 LRRC26
nsv615987	Chr.9:136939743 - 136947810 on Build GRCh38	Loss	FBXW5 C8G
nsv469918	Chr.9:136359865 - 137173890 on Build GRCh38	Loss	LOC100128593 FBXW5 SEC16A HSPC324 SNORA17A PHPT1 EGFL7 CCDC183-AS1 CLIC3 LCN6 MAMDC4 MIR6722 MIR3621 NPDC1 TRAF2 MIR4673 C9orf172 NOTCH1 PTGDS C8G ABCA2 C9orf163 MIR126 MIR4292 SDCCAG3 CCDC183 PRR31 NALT1 MIR4674 INPP5E MAN1B1-AS1 LCN10 SAPCD2 LCN15 ENTPD2 LINC01451 EDF1 UAP1L1 C9orf142 RABL6 LCNL1 C9orf139 SNAPC4 CARD9 TMEM210 DPP7 MIR4479 MAN1B1 LOC101930307 GRIN1 FUT7 SNHG7 LCN12 FAM69B SNORA17B AGPAT2 LCN8 LRRC26 PMPCA TMEM141 DNLZ
esv2422220	Chr.9:136584135 - 137350098 on Build GRCh38	Deletion	LOC100128593 FBXW5 HSPC324 SNORA17A PHPT1 EGFL7 TOR4A CCDC183-AS1 CLIC3 LCN6 MAMDC4 MIR6722 MIR3621 RNF208 NPDC1 TRAF2 STPG3 CYSRT1 FAM166A C9orf172 PTGDS C8G ABCA2 MIR126 MIR4292 CCDC183 PRR31 NELFB EXD3 TPRN MAN1B1-AS1 LCN10 NRARP SAPCD2 LCN15 ENTPD2 LINC01451 EDF1 UAP1L1 C9orf142 RABL6 NDOR1 LCNL1 SSNA1 C9orf139 TUBB4B RNF224 TMEM210 DPP7 C9orf173-AS1 MIR4479 MAN1B1 SLC34A3 LOC101930307 ANAPC2 GRIN1 FUT7 SNHG7 LCN12 FAM69B SNORA17B TMEM203 AGPAT2 LCN8 LRRC26 TMEM141
nsv482133	Chr.9:136940436 - 136944721 on Build GRCh38	Gain	FBXW5

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Gene Ontology Categories:

Process(es)

mitotic nuclear division
regulation of centrosome duplication
protein ubiquitination
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
proteasome-mediated ubiquitin-dependent protein catabolic process

Function(s)

protein binding
protein kinase binding