Hs02136499_cn

• Gene Symbol: HGS
• Assay Reference Genome Location: Chr.17:81693743 on build GRCh38
• Cytoband: 17q25.3

Target Gene Details

• Entrez Gene ID: 9146
• Gene Name: hepatocyte growth factor-regulated tyrosine kinase substrate
• Gene Aliases: HRS
• Location: Chr.17:81683932-81702121 on Build GRCh38
• Assay Gene Location: Overlaps Exon 11 - Intron 11

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
HGS	NM_004712.4			NP_004703.1
	XM_011525463.2			XP_011523765.1
	XM_017025297.1			XP_016880786.1
	XM_017025298.1			XP_016880787.1
	AF260566.1			AAF82361.1
	AK303800.1
	BC003565.1			AAH03565.1
	BT009754.1			AAP88756.1
	D84064.1			BAA23366.1
	KU178466.1
	KU178467.1
	U43895.1			AAC51929.1

Target Gene Details

• Entrez Gene ID: 102465471
• Gene Name: microRNA 6786
• Gene Aliases: hsa-mir-6786
• Location: Chr.17:81693757-81693869 on Build GRCh38
• Assay Gene Location: Overlaps - Exon 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
MIR6786	NR_106844.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv26223	Chr.17:80659041 - 81736487 on Build GRCh38	Gain+Loss	HGS LOC107985022 BAIAP2 AATK MIR4740 MIR3186 CHMP6 LOC100129503 CCDC137 CEP131 FAAP100 RPTOR TMEM105 OXLD1 ARL16 PDE6G LOC107985021 MIR657 LOC105371925 FSCN2 MIR6786 ACTG1 TSPAN10 MIR3065 TEPSIN SLC38A10 BAHCC1 LOC101928855 LOC100130370 LOC105371921 SLC25A10 MIR338 AATK-AS1 LOC400627 C17orf89 MRPL12 BAIAP2-AS1 LINC00482 NPLOC4 MIR1250
nsv428351	Chr.17:81152631 - 83064073 on Build GRCh38	Gain	HGS NOTUM RAB40B PCYT2 MIR4740 RAC3 LOC105376790 CCDC137 CEP131 MCRIP1 FAAP100 TMEM105 LOC105371944 PPP1R27 FN3KRP ARL16 PDE6G NARF LOC105371925 MIR6786 B3GNTL1 ACTG1 SLC38A10 SECTM1 SLC25A10 FN3K MYADML2 ALYREF SNORD134 MRPL12 GCGR MIR6787 SIRT7 TEX19 OGFOD3 LINC00482 NPLOC4 UTS2R CSNK1D AATK LOC105376791 MIR3186 ASPSCR1 P4HB DUS1L RFNG GPS1 FOXK2 OXLD1 CCDC57 ANAPC11 DCXR FSCN2 FASN TSPAN10 TEPSIN LOC101929552 MAFG-AS1 HEXDC LRRC45 CD7 BAHCC1 WDR45B NPB LOC100130370 ZNF750 MAFG TBCD AATK-AS1 C17orf62 C17orf89 LOC101929511 PYCR1 ARHGDIA STRA13 SLC16A3 MIR4525
nsv470620	Chr.17:81516973 - 82064485 on Build GRCh38	Loss	HGS NOTUM PCYT2 RAC3 CCDC137 ASPSCR1 P4HB DUS1L RFNG MCRIP1 FAAP100 GPS1 OXLD1 PPP1R27 ARL16 PDE6G ANAPC11 DCXR FSCN2 MIR6786 TSPAN10 MAFG-AS1 LRRC45 NPB MAFG SLC25A10 MYADML2 ALYREF MRPL12 PYCR1 GCGR ARHGDIA STRA13 SIRT7 NPLOC4
nsv952390	Chr.17:81637175 - 81860124 on Build GRCh38	Deletion	MIR6786 HGS TSPAN10 SLC25A10 CCDC137 P4HB MCRIP1 MRPL12 GCGR OXLD1 PPP1R27 ARL16 PDE6G

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

protein targeting to lysosome
autophagy
signal transduction
negative regulation of cell proliferation
membrane invagination
positive regulation of gene expression
endosomal transport
multivesicular body assembly
negative regulation of epidermal growth factor receptor signaling pathway
regulation of protein catabolic process
regulation of MAP kinase activity
negative regulation of JAK-STAT cascade
protein localization to membrane
positive regulation of exosomal secretion

Function(s)

protein binding
protein domain specific binding
metal ion binding