Hs02139331_cn

• Gene Symbol: PPP3CA
• Assay Reference Genome Location: Chr.4:101024299 on build GRCh38
• Cytoband: 4q24

Target Gene Details

• Entrez Gene ID: 5530
• Gene Name: protein phosphatase 3 catalytic subunit alpha
• Gene Aliases: CALN, CALNA, CALNA1, CCN1, CNA1, PPP2B
• Location: Chr.4:101023430-101347471 on Build GRCh38
• Assay Gene Location: Within Exon 15

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PPP3CA	NM_000944.4	14	3807	NP_000935.1
	NM_001130691.1	13	3777	NP_001124163.1
	NM_001130692.1	12	3651	NP_001124164.1
	XM_017008365.1	14	3111	XP_016863854.1
	AL353950.1	14	3538	CAB89253.1
	BC025714.1			AAH25714.1
	EU192652.1	12	3651
	EU192653.1	8	3124

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv3601585	Chr.4:100952589 - 101052381 on Build GRCh38	Gain	PPP3CA

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

protein phosphatase

Gene Ontology Categories:

Process(es)

G1/S transition of mitotic cell cycle
response to amphetamine
protein dephosphorylation
protein import into nucleus
calcium ion transport
Wnt signaling pathway, calcium modulating pathway
transition between fast and slow fiber
cardiac muscle hypertrophy in response to stress
dephosphorylation
calcineurin-NFAT signaling cascade
multicellular organismal response to stress
negative regulation of chromatin binding
cellular response to drug
Fc-epsilon receptor signaling pathway
T cell activation
positive regulation of transcription from RNA polymerase II promoter
negative regulation of insulin secretion
skeletal muscle fiber development
negative regulation of dendrite morphogenesis
modulation of synaptic transmission
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of NFAT protein import into nucleus
response to calcium ion
excitatory postsynaptic potential
cellular response to glucose stimulus
positive regulation of cardiac muscle hypertrophy in response to stress

Function(s)

protein serine/threonine phosphatase activity
calcium ion binding
protein binding
calmodulin binding
drug binding
enzyme binding
calmodulin-dependent protein phosphatase activity
protein heterodimerization activity
protein dimerization activity