Hs02149508_cn

• Gene Symbol: LIF
• Assay Reference Genome Location: Chr.22:30242815 on build GRCh38
• Cytoband: 22q12.2

Target Gene Details

• Entrez Gene ID: 3976
• Gene Name: leukemia inhibitory factor
• Gene Aliases: CDF, DIA, HILDA, MLPLI
• Location: Chr.22:30240447-30246851 on Build GRCh38
• Assay Gene Location: Within Exon 3

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
LIF	NM_001257135.1	2	1422	NP_001244064.1
	NM_002309.4	3	1601	NP_002300.1
	X13967.1	3	1489	CAA32147.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv834173	Chr.22:30119103 - 30262288 on Build GRCh38	Loss	MGC20647 LIF HORMAD2
nsv834174	Chr.22:30223771 - 30350926 on Build GRCh38	Gain+Loss	SF3A1 MGC20647 OSM LIF GATSL3 TBC1D10A
nsv829171	Chr.22:30202041 - 30647591 on Build GRCh38	Loss	RNF215 KIAA1656 TCN2 MGC20647 SEC14L3 SDC4P SEC14L2 GAL3ST1 SEC14L6 HORMAD2 SLC35E4 SF3A1 CCDC157 PES1 OSM LIF GATSL3 SEC14L4 MTFP1 TBC1D10A

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

cytokine, intercellular signal molecule

Gene Ontology Categories:

Process(es)

blood vessel remodeling
immune response
multicellular organism development
embryo implantation
positive regulation of cell proliferation
negative regulation of cell proliferation
positive regulation of neuron projection development
negative regulation of angiogenesis
stem cell population maintenance
organ regeneration
positive regulation of peptidyl-serine phosphorylation
positive regulation of peptidyl-serine phosphorylation of STAT protein
tyrosine phosphorylation of Stat3 protein
positive regulation of tyrosine phosphorylation of Stat1 protein
positive regulation of tyrosine phosphorylation of Stat3 protein
positive regulation of MAPK cascade
positive regulation of macrophage differentiation
negative regulation of meiotic nuclear division
positive regulation of transcription from RNA polymerase II promoter
decidualization
negative regulation of hormone secretion
lung alveolus development
muscle organ morphogenesis
neuron development
astrocyte differentiation
positive regulation of astrocyte differentiation
leukemia inhibitory factor signaling pathway
stem cell differentiation
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of corticotropin secretion
retina development in camera-type eye
transdifferentiation
lung vasculature development
lung lobe morphogenesis
trophoblast giant cell differentiation
spongiotrophoblast differentiation
negative regulation of ERK1 and ERK2 cascade
positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
regulation of metanephric nephron tubule epithelial cell differentiation
positive regulation of protein localization to nucleus
positive regulation of histone H3-K27 acetylation
regulation of RNA polymerase II regulatory region sequence-specific DNA binding

Function(s)

transcription factor activity, RNA polymerase II transcription factor recruiting
receptor binding
cytokine activity
leukemia inhibitory factor receptor binding
protein binding
growth factor activity