Hs02189617_cn

• Gene Symbol: MAPK8IP3
• Assay Reference Genome Location: Chr.16:1770276 on build GRCh38
• Cytoband: 16p13.3

Target Gene Details

• Entrez Gene ID: 23162
• Gene Name: mitogen-activated protein kinase 8 interacting protein 3
• Gene Aliases: JIP-3, JIP3, JSAP1, SYD2, syd
• Location: Chr.16:1706183-1770317 on Build GRCh38
• Assay Gene Location: Overlaps - Exon 34

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
MAPK8IP3	NM_001040439.1			NP_001035529.1
	NM_001318852.1			NP_001305781.1
	NM_015133.4			NP_055948.2
	XM_005255190.2			XP_005255247.1
	XM_006720869.2			XP_006720932.1
	XM_011522429.2			XP_011520731.1
	XM_011522430.2			XP_011520732.1
	XM_011522431.2			XP_011520733.1
	XM_011522432.2			XP_011520734.1
	XM_011522433.2			XP_011520735.1
	XM_017023079.1			XP_016878568.1
	XM_017023080.1			XP_016878569.1
	XM_017023081.1			XP_016878570.1
	AB028989.2
	AI291346.1
	BC150266.1

Target Gene Details

• Entrez Gene ID: 4832
• Gene Name: NME/NM23 nucleoside diphosphate kinase 3
• Gene Aliases: DR-nm23, NDPK-C, NDPKC, NM23-H3, NM23H3, c371H6.2
• Location: Chr.16:1770320-1771750 on Build GRCh38
• Assay Gene Location: Overlaps - Exon 5

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
NME3	NM_002513.2			NP_002504.2
	XM_005255332.4			XP_005255389.1
	XM_011522503.2			XP_011520805.1
	XM_011522504.2			XP_011520806.1
	BC000250.1			AAH00250.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv571169	Chr.16:1729694 - 1789022 on Build GRCh38	Loss	MAPK8IP3 SPSB3 NME3 NUBP2 MRPS34 MIR3177 EME2
esv2422427	Chr.16:10001 - 2723164 on Build GRCh38	Duplication	FAM173A BAIAP3 C16orf59 PGP TPSAB1 NTHL1 C1QTNF8 MEIOB LOC106660606 PRSS29P MIR6859-4 PRSS27 RHBDL1 UBE2I MIR3176 SNHG19 TMEM204 HS3ST6 RHOT2 WASIR2 SNORA64 RAB40C ZNF598 CCDC154 SLC9A3R2 FBXL16 LINC00235 CACNA1H GFER NPRL3 CCDC78 WDR24 CEMP1 MAPK8IP3 WFIKKN1 KCTD5 HN1L LOC105371184 MIR4717 PDIA2 MIR3178 LINC00254 LMF1-AS1 NHLRC4 MIR3180-5 PRR25 SOX8 EME2 TPSD1 MIR3677 PRR35 HBA2 MIR5587 HBM RHBDF1 PIGQ CLCN7 LOC107984876 LOC105371047 TMEM8A SPSB3 MIR4516 HBQ1 LMF1 GNG13 IFT140 CASKIN1 AXIN1 RGS11 DECR2 CCNF MCRIP2 LOC105371049 NUBP2 NME4 FLJ42627 SYNGR3 TELO2 DNASE1L2 METRN TPSB2 NOXO1 SNORD60 RPL3L ABCA17P TSR3 STUB1 LOC652276 AMDHD2 NTN3 SSTR5-AS1 NME3 E4F1 NPW PKD1 METTL26 MIR3177 MLST8 LOC100287175 RAB26 SSTR5 SNORA10 CHTF18 MSRB1 MIR1225 RAB11FIP3 LOC100134368 TSC2 ATP6V0C ERVK13-1 RNF151 LOC101929280 C16orf91 HBA1 JMJD8 IGFALS MPG LOC105371046 LOC105371038 CAPN15 FAM234A FAHD1 DDX11L10 LOC729652 RPL23AP5 MRPL28 MIR6768 TBL3 ABCA3 SNRNP25 CRAMP1 RPUSD1 ECI1 MSLN LOC105371045 MIR6511B1 SNORA78 PDPK1 GNPTG TRAF7 POLR3K NARFL UNKL RNPS1 NDUFB10 MIR940 LOC107987233 TBC1D24 MIR6767 HAGH ARHGDIG LUC7L WDR90 PTX4 RPS2 MRPS34 TPSG1 HBZ MIR662 HAGHL BRICD5 SNHG9
nsv571172	Chr.16:1764390 - 1817039 on Build GRCh38	Loss	MAPK8IP3 SPSB3 IGFALS NME3 NUBP2 MRPS34 EME2 HAGH
nsv1160328	Chr.16:1704619 - 1797867 on Build GRCh38	Deletion	MAPK8IP3 SPSB3 IGFALS NME3 NUBP2 MRPS34 MIR3177 EME2
nsv571171	Chr.16:1757779 - 1804539 on Build GRCh38	Gain+Loss	MAPK8IP3 SPSB3 IGFALS NME3 NUBP2 MRPS34 EME2
dgv4856n54	Chr.16:1600945 - 1813519 on Build GRCh38	Loss	MAPK8IP3 SPSB3 HN1L CRAMP1 IFT140 EME2 HAGH IGFALS NME3 NUBP2 MRPS34 LOC105371046 MIR3177
nsv471069	Chr.16:1754356 - 1791032 on Build GRCh38	Loss	MAPK8IP3 SPSB3 IGFALS NME3 NUBP2 MRPS34 EME2
nsv1051692	Chr.16:1505070 - 1866102 on Build GRCh38	Loss	MAPK8IP3 LOC105371047 SPSB3 HN1L MEIOB CRAMP1 IFT140 EME2 HAGH IGFALS NME3 NUBP2 MRPS34 LOC105371046 MIR3177 TMEM204 FAHD1 TELO2
nsv827500	Chr.16:1761258 - 1795126 on Build GRCh38	Gain	MAPK8IP3 SPSB3 IGFALS NME3 NUBP2 MRPS34 EME2
nsv571173	Chr.16:1767596 - 1780436 on Build GRCh38	Loss	MAPK8IP3 SPSB3 NME3 MRPS34 EME2
nsv518641	Chr.16:1645775 - 1835631 on Build GRCh38	Loss	MAPK8IP3 SPSB3 HN1L MEIOB CRAMP1 EME2 HAGH IGFALS NME3 NUBP2 MRPS34 MIR3177 FAHD1
nsv457336	Chr.16:1752231 - 1791032 on Build GRCh38	Loss	MAPK8IP3 SPSB3 IGFALS NME3 NUBP2 MRPS34 EME2
nsv952900	Chr.16:1724500 - 1827999 on Build GRCh38	Deletion	MAPK8IP3 SPSB3 IGFALS NME3 NUBP2 MRPS34 MIR3177 FAHD1 EME2 HAGH

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

scaffold/adaptor protein, kinase

Gene Ontology Categories:

Process(es)

in utero embryonic development
activation of JUN kinase activity
axon guidance
respiratory gaseous exchange
protein localization
post-embryonic development
regulation of gene expression
vesicle-mediated transport
forebrain development
regulation of JNK cascade
lung alveolus development
lung morphogenesis
purine nucleotide metabolic process
nucleoside diphosphate phosphorylation
GTP biosynthetic process
pyrimidine nucleotide metabolic process
UTP biosynthetic process
CTP biosynthetic process
apoptotic process
nucleoside triphosphate biosynthetic process
regulation of apoptotic process

Function(s)

MAP-kinase scaffold activity
JUN kinase binding
kinesin binding
receptor signaling complex scaffold activity
mitogen-activated protein kinase kinase binding
mitogen-activated protein kinase kinase kinase binding
nucleoside diphosphate kinase activity
protein binding
ATP binding
metal ion binding